Zhai Jiajia, Zhang Junyan, He Jingfang, Li Guanqun, Hao Guimin
Reproductive Center, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Department of Clinical Epidemiology and Evidence-Based Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, People's Republic of China.
Risk Manag Healthc Policy. 2023 Aug 31;16:1703-1718. doi: 10.2147/RMHP.S422969. eCollection 2023.
This study aims to investigate the impact of the Chinese New Year (CNY) holiday season on the outcomes of In Vitro Fertilization (IVF) fresh embryo transfer cycles.
This retrospective study analyzed 4688 patients who received their first IVF fresh cycle attempt between January 2017 and October 2021. Of these, 4449 women underwent IVF during non-holiday seasons, while 239 women were treated during the CNY holiday season. The study included women who underwent IVF treatment during the specified time frame. The primary outcome was the live birth rate (LBR).
The study found that the LBR of IVF performed during the CNY holiday season was 32.22%, which is significantly lower than that of the non-holiday season (43.38%, p<0.001). Multivariate logistic regression analysis showed that the CNY holiday season (OR=0.62, 95% CI 0.47-0.82, p=0.001) was an independent factor associated with the live birth rate. Propensity score matching (PSM) data analysis showed that the LBR in the CNY holiday season group was 31.78% compared to 42.64% in the non-holiday season group (p=0.005). Inverse probability of treatment weighting (IPTW) data also indicated that the CNY holiday season had a lower LBR than the non-holiday season (OR=0.64, 95% CI 0.47-0.87, p=0.005).
IVF performed during the CNY holiday season results in a lower live birth rate, potentially indicating that certain lifestyle adjustments during this period, such as unhealthy dietary, tobacco and alcohol usage, sleep disruption, and emotional stress experienced could have some influence on the outcomes.
本研究旨在调查中国农历新年（春节）假期对体外受精（IVF）新鲜胚胎移植周期结局的影响。
这项回顾性研究分析了2017年1月至2021年10月期间接受首次IVF新鲜周期尝试的4688例患者。其中，4449名女性在非假期期间接受了IVF，而239名女性在春节假期期间接受了治疗。该研究纳入了在指定时间范围内接受IVF治疗的女性。主要结局是活产率（LBR）。
研究发现，春节假期期间进行IVF的活产率为32.22%，显著低于非假期期间（43.38%，p<0.001）。多因素逻辑回归分析显示，春节假期期间（OR=0.62，95%CI 0.47-0.82，p=0.001）是与活产率相关的独立因素。倾向评分匹配（PSM）数据分析显示，春节假期期间组的活产率为31.78%，而非假期期间组为42.64%（p=0.005）。治疗逆概率加权（IPTW）数据也表明，春节假期期间的活产率低于非假期期间（OR=0.64，95%CI 0.47-0.87，p=0.005）。
春节假期期间进行IVF会导致较低的活产率，这可能表明在此期间某些生活方式的调整，如不健康的饮食、吸烟和饮酒、睡眠中断以及经历的情绪压力，可能会对结局产生一些影响。
