Yang Yuanyuan, Hou Zhaojuan, Qiu Huiyu, Chang Tianli, Liu Nenghui, Liu Donge, Li Yumei, Zhao Jing, Zhang Qiong, Yao Zhongyuan, Tian Fen, Yang Tianli, Li Yanping
Reproductive Medicine Center, Xiangya Hospital of Central South University, No.87 Xiangya Road, Changsha, 410008, Hunan, P R China.
Clinical Research Center for Women's Reproductive Health in Hunan Province, No.87 Xiangya Road, Changsha, 410008, Hunan, P R China.
Sci Rep. 2025 Jul 2;15(1):23339. doi: 10.1038/s41598-025-05029-6.
To evaluate whether the Spring Festival has an effect on the outcomes of patients undergoing their first embryo transfer (ET) via in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We conducted a retrospective cohort study involving 11,625 first ET cycles were performed at a university-affiliated hospital between January 2014 and March 2022. Women who underwent ET during the peri-Spring Festival periods were designated as the Festival Group, while the remainder were categorized as the Non-Festival Group. Multivariate logistic regression and propensity score matching (PSM) were applied to assess the impact of the "Spring Festival Effect" on pregnancy outcomes. Prior to PSM, patients in Festival Group had lower clinical pregnancy rate (44.39% vs. 52.50%, P < 0.001), implantation rate (34.41% vs. 40.43%, P < 0.001), ongoing pregnancy rate (38.71% vs. 47.15%, P < 0.001), and live birth rate (37.33% vs. 44.82%, P < 0.001). After controlling for confounders, a similar trend remained in the PSM analysis with matching ratios ranging from 1:1 to 1:4. In the multivariable regression analysis, the Spring Festival was found to be an independent risk factor for poor prognosis. These findings indicated that sociocultural events, represented by the Spring Festival, decreased the chances of IVF/ICSI success, underscoring the importance for clinicians and patients to be more vigilant with healthcare during major social events.
为评估春节是否会对接受首次体外受精/卵胞浆内单精子注射（IVF/ICSI）胚胎移植（ET）的患者结局产生影响。我们进行了一项回顾性队列研究，纳入了2014年1月至2022年3月期间在一家大学附属医院进行的11625个首次ET周期。在春节前后接受ET的女性被指定为节日组，其余女性被归类为非节日组。采用多因素逻辑回归和倾向评分匹配（PSM）来评估“春节效应”对妊娠结局的影响。在PSM之前，节日组患者的临床妊娠率较低（44.39%对52.50%，P < 0.001）、着床率较低（34.41%对40.43%，P < 0.001）、持续妊娠率较低（38.71%对47.15%，P < 0.001）和活产率较低（37.33%对44.82%，P < 0.001）。在控制混杂因素后，PSM分析中仍存在类似趋势，匹配比例范围为1:1至1:4。在多变量回归分析中，发现春节是预后不良的独立危险因素。这些发现表明，以春节为代表的社会文化事件降低了IVF/ICSI成功的机会，强调了临床医生和患者在重大社会事件期间对医疗保健更加警惕的重要性。
