Open Innovation Institute, Kyoto University, Kyoto, Japan.
Faculty of Science and Technology, Keio University, Yokohama, Kanagawa, Japan.
Sci Rep. 2021 Jun 7;11(1):11999. doi: 10.1038/s41598-021-91363-4.
Countless studies in animals have shown how housing environments and behaviors can significantly affect anxiety and brain health, giving valuable insight as to whether this is applicable in the human context. The relationship between housing, behavior, brain health, and mental wellbeing in humans remains poorly understood. We therefore explored the interaction of housing quality, weekend/holiday sedentary behavior, brain structure, and anxiety in healthy Japanese adults. Whole-brain structural magnetic resonance imaging (MRI) methods based on gray matter volume and fractional anisotropy were used as markers for brain health. Correlation tests were conducted, and then adjusted for multiple comparisons using the False Discovery Rate method. Housing quality and weekend/holiday sedentary behavior were associated with fractional anisotropy, but not with gray matter volume. Fractional anisotropy showed significant associations with anxiety. Lastly, both weekend/holiday sedentary behavior and housing quality were indirectly associated with anxiety through fractional anisotropy. These results add to the limited evidence surrounding the relationship among housing, behavior, and the brain. Furthermore, these results show that behavior and housing qualities can have an indirect impact on anxiety through neurobiological markers such as fractional anisotropy.
无数动物研究表明，居住环境和行为方式会极大地影响焦虑和大脑健康，这为我们了解人类环境中的情况提供了有价值的见解。人类的居住环境、行为、大脑健康和心理健康之间的关系仍未得到充分理解。因此，我们探索了居住质量、周末/假日久坐行为、大脑结构和健康的日本成年人的焦虑之间的相互作用。基于灰质体积和各向异性分数的全脑结构磁共振成像 (MRI) 方法被用作大脑健康的标志物。我们进行了相关测试，并使用 False Discovery Rate 方法进行了多次比较调整。居住质量和周末/假日久坐行为与各向异性分数相关，但与灰质体积无关。各向异性分数与焦虑显著相关。最后，周末/假日久坐行为和居住质量通过各向异性分数与焦虑呈间接关联。这些结果为居住环境、行为和大脑之间的关系提供了有限的证据。此外，这些结果表明，行为和居住质量可以通过各向异性分数等神经生物学标志物对焦虑产生间接影响。
