Wang Yiren, Li Junlin, Han Hukui, Huang Huihui, Du Huan, Cheng Lianying, Ma Cui, Cai Yongxiang, Li Gang, Tao Jianhong, Cheng Panke
Institute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
iScience. 2023 Aug 18;26(9):107662. doi: 10.1016/j.isci.2023.107662. eCollection 2023 Sep 15.
Morbidity and mortality caused by acute myocardial infarction (AMI) are on the rise, posing a grave threat to the health of the general population. Up to now, interventional, surgical, and pharmaceutical therapies have been the main treatment methods for AMI. Effective and timely reperfusion therapy decreases mortality, but it cannot stimulate myocardial cell regeneration or reverse ventricular remodeling. Cell therapy, gene therapy, immunotherapy, anti-inflammatory therapy, and several other techniques are utilized by researchers to improve patients' prognosis. In recent years, biomaterials for AMI therapy have become a hot spot in medical care. Biomaterials furnish a microenvironment conducive to cell growth and deliver therapeutic factors that stimulate cell regeneration and differentiation. Biomaterials adapt to the complex microenvironment and respond to changes in local physical and biochemical conditions. Therefore, environmental factors and material properties must be taken into account when designing biomaterials for the treatment of AMI. This article will review the factors that need to be fully considered in the design of biological materials.
急性心肌梗死（AMI）所致的发病率和死亡率呈上升趋势，对普通人群的健康构成严重威胁。到目前为止，介入治疗、手术治疗和药物治疗一直是AMI的主要治疗方法。有效且及时的再灌注治疗可降低死亡率，但它无法刺激心肌细胞再生或逆转心室重构。研究人员利用细胞治疗、基因治疗、免疫治疗、抗炎治疗及其他一些技术来改善患者的预后。近年来，用于AMI治疗的生物材料已成为医疗保健领域的一个热点。生物材料提供有利于细胞生长的微环境，并递送刺激细胞再生和分化的治疗因子。生物材料能适应复杂的微环境并对局部物理和生化条件的变化做出反应。因此，在设计用于治疗AMI的生物材料时，必须考虑环境因素和材料特性。本文将综述生物材料设计中需要充分考虑的因素。
