Abdeen Heba A, Helmy Zeinab M, Elnaggar Moustafa I, Aldhahi Monira I, Taha Mona Mohamed, Marques-Sule Elena, Amin Doaa I, Ibrahim Bassem S, Abdel Aziz Ahmed, Castiglione Vincenzo, Atef Hady
Department of Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics, Faculty of Physical Therapy, Cairo University, Giza, 11432, Egypt.
Faculty of Physical Therapy, Heliopolis University for Sustainable Development, Giza, Egypt.
Int J Gen Med. 2023 Aug 30;16:3933-3945. doi: 10.2147/IJGM.S420933. eCollection 2023.
Multiple comorbidities and physiological changes play a role in a range of heart failure conditions and influence the most effective approach to exercise-based rehabilitation. This research aimed to examine and compare the outcomes of continuous training at three different intensities, focusing on left ventricular (LV) remodeling, functional capacity, and quality of life among patients with heart failure with reduced ejection fraction (HFrEF).
In this randomized control trial, a total of 60 male patients (average age: 54.33 ±2.35 years) with HFrEF were randomly allocated into three groups: 1) High-intensity continuous training group (HICT), 2) Moderate-intensity continuous training group (MICT), and 3) Low-intensity continuous training group (LICT). All the training was performed on a bicycle ergometer 3 times/week for 12 weeks. Echocardiographic parameters (left ventricular ejection fraction, left ventricular end-diastolic dimension, left ventricular end-systolic dimension, N-terminal pro-B-type natriuretic peptide (NT-proBNP), quality of life (Minnesota Living with Heart Failure Questionnaire), and functional capacity (6-minute walking test) were assessed before and the end of the study.
The HICT group demonstrated the greatest improvements in all measured variables when compared to the other two groups ( < 0.05). These findings were consistent across all measured outcomes.
It was determined that HICT appears to yield the most favorable outcomes in enhancing echocardiographic measures, NT-proBNP levels, quality of life, and functional capacity among HFrEF patients.
多种合并症和生理变化在一系列心力衰竭病症中起作用，并影响基于运动的康复的最有效方法。本研究旨在检查和比较三种不同强度的持续训练的结果，重点关注射血分数降低的心力衰竭（HFrEF）患者的左心室（LV）重塑、功能能力和生活质量。
在这项随机对照试验中，总共60名患有HFrEF的男性患者（平均年龄：54.33±2.35岁）被随机分为三组：1）高强度持续训练组（HICT），2）中等强度持续训练组（MICT），和3）低强度持续训练组（LICT）。所有训练均在自行车测力计上进行，每周3次，共12周。在研究开始前和结束时评估超声心动图参数（左心室射血分数、左心室舒张末期内径、左心室收缩末期内径、N末端B型利钠肽原（NT-proBNP））、生活质量（明尼苏达心力衰竭生活问卷）和功能能力（6分钟步行试验）。
与其他两组相比，HICT组在所有测量变量上都有最大的改善（<0.05）。这些发现在所有测量结果中都是一致的。
已确定HICT似乎在改善HFrEF患者的超声心动图测量、NT-proBNP水平、生活质量和功能能力方面产生最有利的结果。
