Laboratoire Pierre Fabre, Centre R&D, Toulouse, France.
Laboratoires Dermatologiques Avène, Pierre Fabre Dermo-Cosmétique, Lavaur, France.
J Eur Acad Dermatol Venereol. 2023 Oct;37 Suppl 6:12-21. doi: 10.1111/jdv.19290.
Blue light (BL), particularly high-energy visible (HEV) light (400-450 nm), can cause skin damage and pigmentation. Therefore, effective sunscreens should offer photoprotection beyond ultraviolet (UV) radiation to also prevent or limit BL-induced cutaneous effects.
To evaluate the in vitro BL photostability and photoprotection properties of nine sunscreens containing the broad-spectrum UV/BL phenylene bis-diphenyltriazine (PBDT or TriAsorB™) filter, together with three other organic UV filters, and to assess the in vivo photoprotection level provided by two of these products against BL-induced skin pigmentation.
In vitro BL photostability and photoprotection factors, comprising the percentage of BL radiation stopped by the product (%BL) and the critical wavelength extended to BL (BL-CW), were determined by spectrophotometry. The in vivo photoprotection provided by two representative sunscreens (i.e. similar formulations, one non-tinted and one tinted) was assessed in two open randomized studies (20 and 16 women, respectively) after exposure of two test areas (with and without sunscreen) on the back of each subject to a 412-nm irradiation dose at 50 J/cm , using instrumental and clinical measurements of skin pigmentation. The percentage sunscreen photoprotective effectiveness (%PPE) was calculated by comparing intrasubject post-exposure pigmentation changes between the with and without sunscreen test areas.
In vitro, the nine PBDT-containing products were highly photostable and had a BL-CW ≥385 nm and a %BL ≥30% (range: 30%-50%), thus allowing effective BL photoprotection. In vivo, both representative sunscreens prevented BL-induced immediate skin pigmentation (1 and 24 h post-exposure) with %PPE values ranging from 50.7% to 75.5% for colorimetric assessments (p < 0.001) and from 31.2% to 72.7% for visual scores (p ≤ 0.001).
All PBDT-containing sunscreens were considered effective at absorbing BL radiation in vitro. The two representative broad-spectrum sunscreens tested in subjects significantly reduced BL-induced immediate skin pigmentation following single exposure to monochromatic BL radiation.
蓝光（BL），尤其是高能可见光（HEV）（400-450nm），可导致皮肤损伤和色素沉着。因此，有效的防晒霜应提供紫外线（UV）辐射以外的光保护，以防止或限制 BL 引起的皮肤效应。
评估九种含有宽谱 UV/BL 二苯并二苯基三嗪（PBDT 或 TriAsorB™）滤光片的防晒霜的体外 BL 光稳定性和光保护性能，以及三种其他有机 UV 滤光片，并评估两种产品提供的体内光保护水平对 BL 诱导的皮肤色素沉着的影响。
通过分光光度法测定体外 BL 光稳定性和光保护因子，包括产品阻挡的 BL 辐射百分比（%BL）和延伸至 BL 的临界波长（BL-CW）。通过仪器和临床测量皮肤色素沉着，在两项开放随机研究中评估两种代表性防晒霜（即相似配方，一种无着色，一种有着色）提供的体内光保护作用（分别有 20 名和 16 名女性），在每位受试者背部的两个测试区域（有和无防晒霜）暴露于 412nm 照射剂量为 50J/cm2后，使用 412nm 照射剂量为 50J/cm2。通过比较有和无防晒霜测试区域的受试者内暴露后色素沉着变化，计算防晒霜的防晒保护有效率（%PPE）。
体外，九种含有 PBDT 的产品具有高度的光稳定性，BL-CW≥385nm，%BL≥30%（范围：30%-50%），因此能够有效提供 BL 光保护。体内，两种代表性防晒霜均能预防 BL 诱导的即时皮肤色素沉着（暴露后 1 小时和 24 小时），色觉评估的%PPE 值范围为 50.7%至 75.5%（p<0.001），视觉评分的%PPE 值范围为 31.2%至 72.7%（p≤0.001）。
所有含有 PBDT 的防晒霜在体外均被认为能有效吸收 BL 辐射。在接受单色 BL 辐射单次照射的受试者中，两种代表性的广谱防晒霜显著减少了 BL 诱导的即时皮肤色素沉着。
