Zou Ming-Feng, Hu Rong, Liu Ying-Xin, Fan Run-Zhu, Xie Xing-Lin, Yin Sheng
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Senior High School, Guangzhou Foreign Language School, Guangzhou 511455, China.
J Asian Nat Prod Res. 2020 Oct;22(10):927-934. doi: 10.1080/10286020.2020.1751618. Epub 2020 Apr 15.
Two highly oxygenated -clerodane diterpenoids, crocleropenes A and B ( and ), together with four known compounds () were isolated from the leaves and twigs of . Their structures were elucidated by combination of extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. and represent the first examples of -clerodane-3,5(10)-diene diterpenoids. Compounds and exhibited weak cytotoxicity against MCF-7 cancer cells with IC values of 35.8 and 40.2 μM, respectively. [Formula: see text].
从[植物名称]的叶和嫩枝中分离出两种高度氧化的克罗丹二萜类化合物，克罗洛佩内斯A和B（[化合物结构简式]），以及四种已知化合物（[化合物结构简式]）。通过广泛的光谱分析和电子圆二色性（ECD）计算相结合的方法阐明了它们的结构。克罗洛佩内斯A和B是克罗丹-3,5(10)-二烯二萜类化合物的首例。化合物[具体化合物编号]和[具体化合物编号]对MCF-7癌细胞表现出较弱的细胞毒性，IC值分别为35.8和40.2 μM。[分子式：见正文]
