Feltelius N, Hedenström H, Hillerdal G, Hällgren R
Ann Rheum Dis. 1986 Sep;45(9):736-40. doi: 10.1136/ard.45.9.736.
Thirty two patients with ankylosing spondylitis were investigated with a set of pulmonary function tests and the results compared with those for a control population. The patients had no complaints about lung symptoms and their chest radiographs were normal. The main pathological findings were reduced lung volumes, a raised closing volume/vital capacity ratio, and a decreased volumic airway conductance. The lung volume reduction correlated with disease duration, thoracic mobility, and degree of acute phase reaction. The stiff spondylitic thorax probably makes the main contribution to the impairment of lung function in these patients, but the findings in this study also suggest an involvement of the small airways. This type of pulmonary function testing seems valuable even in patients with ankylosing spondylitis without lung symptoms and it might be used as a tool in the staging of the disease, to evaluate treatment and to differentiate from fibrosis.
对32例强直性脊柱炎患者进行了一系列肺功能测试，并将结果与对照组人群的结果进行了比较。这些患者没有肺部症状主诉，胸部X线片也正常。主要病理表现为肺容积减少、闭合气量/肺活量比值升高和单位气道传导率降低。肺容积减少与病程、胸廓活动度和急性期反应程度相关。僵硬的脊柱炎胸廓可能是这些患者肺功能损害的主要原因，但本研究结果也提示小气道受累。这种肺功能测试即使在没有肺部症状的强直性脊柱炎患者中似乎也有价值，它可作为疾病分期、评估治疗及与纤维化鉴别诊断的工具。
