Kim Seung Chan, Lee Yeong Guk, Park Si-Bog, Kim Tae Hwan, Lee Kyu Hoon
Department of Rehabilitation Medicine, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.
Department of Rheumatology, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.
Ann Rehabil Med. 2017 Dec;41(6):990-997. doi: 10.5535/arm.2017.41.6.990. Epub 2017 Dec 28.
To determine if there is muscle mass reduction in patients with ankylosing spondylitis (AS) compared to the general population and to examine the relationship between skeletal muscle mass, quality of life (QOL), strength, and mobility in patients with AS.
A total of 30 AS patients were enrolled in this study. Skeletal muscle mass was measured by bioelectrical impedance analysis, and it was expressed as the skeletal muscle mass index (SMI). QOL was assessed using the EuroQOL (EQ-5D). To measure mobility, the modified Schöber test and chest expansion test were used. To measure grip strength as a measure of muscle strength, we used the hydraulic hand dynamometer. Additionally, we divided the patients into two groups according to the degree of X-ray finding and compared the differences between the two groups.
There was no significant reduction in skeletal muscle mass in patients with AS compared to the general population. Also, there was no significant correlation between SMI and QOL. On the other hand, there was a significant positive correlation between SMI and mobility, and grip strength. A significant positive correlation was found between mobility and QOL. Additionally, there was a statistically significant difference in mobility between the two groups according to the degree of X-ray finding.
Maintaining muscle mass in AS patients may not be helpful for improving QOL, but it may contribute to achieving adequate mobility and strength.
确定与普通人群相比，强直性脊柱炎（AS）患者是否存在肌肉量减少，并研究AS患者骨骼肌量、生活质量（QOL）、力量和活动能力之间的关系。
本研究共纳入30例AS患者。通过生物电阻抗分析测量骨骼肌量，并以骨骼肌量指数（SMI）表示。使用欧洲五维健康量表（EQ-5D）评估生活质量。为测量活动能力，采用改良Schöber试验和胸廓扩张试验。为测量作为肌肉力量指标的握力，我们使用液压式握力计。此外，我们根据X线检查结果的程度将患者分为两组，并比较两组之间的差异。
与普通人群相比，AS患者的骨骼肌量没有显著减少。此外，SMI与生活质量之间没有显著相关性。另一方面，SMI与活动能力和握力之间存在显著正相关。活动能力与生活质量之间存在显著正相关。此外，根据X线检查结果的程度，两组之间的活动能力存在统计学显著差异。
维持AS患者的肌肉量可能无助于改善生活质量，但可能有助于实现足够的活动能力和力量。
