Shan Jingyi, Liu Suxian, Liu Haoyue, Yuan Jianye, Lin Jiang
Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2023 Aug 22;14:1221849. doi: 10.3389/fphar.2023.1221849. eCollection 2023.
Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions.
溃疡性结肠炎（UC）是一种难治性炎症性肠病，包括5-氨基水杨酸、糖皮质激素、免疫抑制剂和生物制剂在内的UC传统治疗方法，在不良反应和经济负担方面，患者和医生都不满意。UC发病机制中肠黏膜屏障的异常已得到证实。清肠栓（QCS）是一种草药制剂，对治疗溃疡性直肠炎有效。QCS及其活性成分的作用机制尚未明确，尤其是在黏膜愈合方面。本综述从肠黏膜屏障角度阐明了QCS的潜在作用机制，以帮助探索未来QCS的研究方向。
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