Wang Qiwen, Hu Zhehui, Li Zhixuan, Liu Tiangang, Bian Guangkai
Department of Urology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
Center of Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Adv Mater. 2023 Sep 7:e2305828. doi: 10.1002/adma.202305828.
At the intersection of synthetic biology and materials science, engineered living materials (ELMs) exhibit unprecedented potential. Possessing unique "living" attributes, ELMs represent a significant paradigm shift in material design, showcasing self-organization, self-repair, adaptability, and evolvability, surpassing conventional synthetic materials. This review focuses on reviewing the applications of ELMs derived from bacteria, fungi, and plants in environmental remediation, eco-friendly architecture, and sustainable energy. The review provides a comprehensive overview of the latest research progress and emerging design strategies for ELMs in various application fields from the perspectives of synthetic biology and materials science. In addition, the review provides valuable references for the design of novel ELMs, extending the potential applications of future ELMs. The investigation into the synergistic application possibilities amongst different species of ELMs offers beneficial reference information for researchers and practitioners in this field. Finally, future trends and development challenges of synthetic biology for ELMs in the coming years are discussed in detail.
在合成生物学与材料科学的交叉领域，工程化活材料（ELMs）展现出前所未有的潜力。具有独特的“生命”属性，ELMs代表了材料设计中重大的范式转变，展现出自组织、自我修复、适应性和进化能力，超越了传统合成材料。本综述聚焦于细菌、真菌和植物来源的ELMs在环境修复、生态友好型建筑和可持续能源方面的应用。该综述从合成生物学和材料科学的角度，全面概述了ELMs在各个应用领域的最新研究进展和新兴设计策略。此外，该综述为新型ELMs的设计提供了有价值的参考，拓展了未来ELMs的潜在应用。对不同种类ELMs协同应用可能性的研究，为该领域的研究人员和从业者提供了有益的参考信息。最后，详细讨论了未来几年ELMs合成生物学的未来趋势和发展挑战。
