Gerber H A, Morris B, Trevella W
Aust J Exp Biol Med Sci. 1986 Jun;64 ( Pt 3):201-13. doi: 10.1038/icb.1986.22.
Experiments were designed to examine the relative contributions of Peyer's patches and mesenteric lymph nodes to the population of circulating immunoglobulin-bearing lymphocytes in sheep. The ileum, with more than 90% of the total Peyer's patches, the mesenteric lymph nodes, or both, were removed from lambs at different stages of development and the composition of the cell populations in lymph from different sources and in the blood was examined. Lambs which had had the ileum removed before or within a few days of birth were deficient in small lymphocytes bearing membrane immunoglobulin. This deficit remained for at least the first year of the animals' lives. Neither the removal of mesenteric lymph nodes nor removal of the ileum had any statistically significant effect on the total output of cells or on the population of IgA-producing cells in lymph draining from the gut.
设计实验以研究派尔集合淋巴结和肠系膜淋巴结对绵羊循环中携带免疫球蛋白淋巴细胞群体的相对贡献。在不同发育阶段从羔羊身上切除含有超过90%总派尔集合淋巴结的回肠、肠系膜淋巴结或两者，并检查来自不同来源的淋巴液和血液中细胞群体的组成。在出生前或出生后几天内切除回肠的羔羊缺乏携带膜免疫球蛋白的小淋巴细胞。这种缺陷至少在动物生命的第一年持续存在。切除肠系膜淋巴结或回肠对细胞的总输出量或从肠道引流的淋巴液中产生IgA的细胞群体均无统计学上的显著影响。
