Vonderviszt F, Simon I
Biochem Biophys Res Commun. 1986 Aug 29;139(1):11-7. doi: 10.1016/s0006-291x(86)80072-9.
A simple approach to domain border prediction in globular proteins is outlined relying on the amino acid sequence only. Statistically determined sequential and association preference data of amino acids were combined to generate short range preference profiles along the polypeptide chains. Domain boundaries correlate with the minima of preference profiles, but some false minima also exist. Possibilities are discussed to exclude the false minima and to further improve the efficiency of the algorithm.
