Peluffo R Daniel, Hernández Julio A
Group of Biophysical Chemistry, Department of Biological Sciences, CENUR Litoral Norte, Universidad de La República, Rivera 1350, CP: 50000 Salto, Uruguay.
Biophysics and Systems Biology Section, Department of Cell and Molecular Biology, Facultad de Ciencias, Universidad de La República, Iguá 4225, CP: 11400 Montevideo, Uruguay.
Biophys Rev. 2023 Jul 17;15(4):539-552. doi: 10.1007/s12551-023-01082-5. eCollection 2023 Aug.
Almost seventy years after its discovery, the sodium-potassium adenosine triphosphatase (the sodium pump) located in the cell plasma membrane remains a source of novel mechanistic and physiologic findings. A noteworthy feature of this enzyme/transporter is its robust stoichiometric ratio under physiological conditions: it sequentially counter-transports three sodium ions and two potassium ions against their electrochemical potential gradients per each hydrolyzed ATP molecule. Here we summarize some present knowledge about the sodium pump and its physiological roles, and speculate whether energetic constraints may have played a role in the evolutionary selection of its characteristic stoichiometric ratio.
在其被发现近70年后，位于细胞质膜上的钠钾腺苷三磷酸酶（钠泵）仍是新的机制和生理学发现的来源。这种酶/转运蛋白的一个显著特征是其在生理条件下稳定的化学计量比：每水解一个ATP分子，它依次逆着电化学势梯度反向转运三个钠离子和两个钾离子。在此，我们总结了一些关于钠泵及其生理作用的现有知识，并推测能量限制是否可能在其特征性化学计量比的进化选择中发挥了作用。
