Schofield P M, Brooks N H, Bennett D H
Br Heart J. 1986 Oct;56(4):327-33. doi: 10.1136/hrt.56.4.327.
Left ventricular function was assessed in 201 patients who presented with angina pectoris and who were subsequently found to have completely normal coronary angiograms. Left ventricular angiograms from 187 patients were suitable for analysis of systolic regional wall motion; 121 were found to be normal and 66 had a total of 115 hypokinetic segments. Patients with hypokinesia had a significantly higher left ventricular end systolic volume and a significantly lower left ventricular ejection fraction and exercise capacity than those in whom regional wall motion was normal. Thirty one per cent of patients with normal wall motion and 30% of those with hypokinesia had a resting left ventricular end diastolic pressure greater than 15 mm Hg. There were significantly more smokers in the group with hypokinetic segments. Thus of patients with angina and normal coronary angiograms, 25% had evidence of left ventricular systolic dysfunction, 20% had evidence of diastolic dysfunction, and 11% had evidence of both systolic and diastolic dysfunction. The results suggest that smoking may be associated with left ventricular regional wall motion abnormalities.
对201例出现心绞痛且随后冠状动脉造影显示完全正常的患者进行了左心室功能评估。187例患者的左心室造影适合分析收缩期节段性室壁运动；其中121例正常，66例共有115个运动减弱节段。与节段性室壁运动正常的患者相比，运动减弱的患者左心室收缩末期容积显著更高，左心室射血分数和运动能力显著更低。室壁运动正常的患者中有31%、运动减弱的患者中有30%静息左心室舒张末期压力大于15 mmHg。运动减弱节段组中的吸烟者显著更多。因此，在心绞痛且冠状动脉造影正常的患者中，25%有左心室收缩功能障碍的证据，20%有舒张功能障碍的证据，11%有收缩和舒张功能障碍的证据。结果表明，吸烟可能与左心室节段性室壁运动异常有关。
