曲唑酮在母乳中的排泄情况。
Excretion of trazodone in breast milk.
作者信息
Verbeeck R K, Ross S G, McKenna E A
出版信息
Br J Clin Pharmacol. 1986 Sep;22(3):367-70. doi: 10.1111/j.1365-2125.1986.tb02903.x.
Abstract
The excretion of breast milk was studied in six lactating women following the oral administration of a single trazodone tablet (50 mg). The milk/plasma ratio of trazodone based on area under the plasma and milk curves was small: 0.142 +/- 0.045 (mean +/- s.d.). Assuming that the babies would drink 500 ml 12 h-1, they would be exposed to less than 0.005 mg kg-1 as compared to 0.77 mg kg-1 for the mothers. It is concluded that exposure of babies to trazodone via breast milk is very small.
摘要
对六名哺乳期妇女口服一片曲唑酮（50毫克）后母乳排泄情况进行了研究。基于血浆和乳汁曲线下面积得出的曲唑酮乳汁/血浆比值较小：0.142±0.045（均值±标准差）。假设婴儿每12小时饮用500毫升乳汁，与母亲的0.77毫克/千克相比，婴儿接触的剂量将低于0.005毫克/千克。得出的结论是，婴儿通过母乳接触曲唑酮的量非常少。
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本文引用的文献
1
Lack of anticholinergic side effects with a new antidepressent--trazodone.一种新型抗抑郁药——曲唑酮没有抗胆碱能副作用。
J Clin Psychiatry. 1980 Mar;41(3):100-4.
2
Excretion of drugs in human breast milk.药物在人乳中的排泄。
Drug Metab Rev. 1981;12(2):261-77. doi: 10.3109/03602538108994032.
3
Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety.曲唑酮：对其药理特性及在抑郁和焦虑治疗中的应用综述
Drugs. 1981 Jun;21(6):401-29. doi: 10.2165/00003495-198121060-00001.
4
Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences.药物在人乳中的排泄：原理、药代动力学及预期后果。
Clin Pharmacokinet. 1980 Jan-Feb;5(1):1-66. doi: 10.2165/00003088-198005010-00001.
5
Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly.曲唑酮在老年人中的药代动力学和药效学特征。
Br J Clin Pharmacol. 1983 Oct;16(4):371-6. doi: 10.1111/j.1365-2125.1983.tb02180.x.
6
Comparative bioavailability of trazodone formulations using stable isotope methodology.使用稳定同位素方法研究曲唑酮制剂的相对生物利用度。
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7
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J Pharm Pharmacol. 1981 Jul;33(7):477-8. doi: 10.1111/j.2042-7158.1981.tb13841.x.
8
Infant growth and human milk requirements. A fresh approach.
Lancet. 1981 Jul 25;2(8239):161-3. doi: 10.1016/s0140-6736(81)90352-4.
9
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10
Studies on metabolism of trazodone. III Species differences.曲唑酮的代谢研究。III 种属差异。
Xenobiotica. 1976 May;6(5):295-306. doi: 10.3109/00498257609151641.
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