生活在丹麦的格陵兰人的鹰爪豆碱氧化多态性
Sparteine oxidation polymorphism in Greenlanders living in Denmark.
作者信息
Brøsen K
出版信息
Br J Clin Pharmacol. 1986 Oct;22(4):415-9. doi: 10.1111/j.1365-2125.1986.tb02911.x.
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2- + 5-dehydrosparteine in a 12 h urine sample ranged from 0.06-3.12 in EM and from 30-480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%-63% in EM. The urinary recovery (% of dose) of sparteine, 2-dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brøsen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies.
对居住在丹麦的185名健康格陵兰人进行的研究显示，鹰爪豆碱氧化似乎具有多态性。6名受试者（3.2%）被表型鉴定为慢代谢者（PM），179名受试者为快代谢者（EM）。12小时尿液样本中鹰爪豆碱与2- + 5-脱氢鹰爪豆碱的代谢率（MR）在快代谢者中为0.06 - 3.12，在慢代谢者中为30 - 480。脱氢鹰爪豆碱的排泄量在慢代谢者中占剂量的比例不到2.2%，在快代谢者中为5.6% - 63%。格陵兰快代谢者中鹰爪豆碱、2-脱氢鹰爪豆碱以及鹰爪豆碱 + 脱氢鹰爪豆碱的总尿液回收率（剂量百分比）低于丹麦快代谢者（布罗森等人，1985年）。相当一部分格陵兰人尿液收集不完全可能解释了这些差异。
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