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Genetically determined sparteine oxidation polymorphism in a Polish population.

作者信息

Orzechowska-Juzwenko K, Pawlik J, Niewiński P, Milejski P, Dembowski J, Turek J, Goździk A, Swiebodzki L, Hora Z

出版信息

Eur J Clin Pharmacol. 1994;46(5):481-3. doi: 10.1007/BF00191917.

DOI:10.1007/BF00191917
PMID:7957549
Abstract

The genetic oxidation polymorphism was determined in 160 healthy Polish volunteers from the south-west of Poland (Wrocław region), using sparteine as a model drug. The results of a Polish population study revealed a bimodal distribution of the sparteine metabolic ratio and showed the existence of two oxidation phenotypes designated as extensive and poor metabolizers. The frequency of poor metabolizers in our study (8.8%) compares well with most results of poor oxidation metabolizers in Caucasian populations.

摘要

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本文引用的文献

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2
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J Med Genet. 1980 Apr;17(2):102-5. doi: 10.1136/jmg.17.2.102.
3
[Drug hydroxylation disorders (debrisoquin type) in a random sample of the Swiss population].
Schweiz Med Wochenschr. 1982 Jul 24;112(30):1061-7.
4
Sparteine metabolism in Canadian Caucasians.
Clin Pharmacol Ther. 1982 Jan;31(1):23-9. doi: 10.1038/clpt.1982.4.
5
Comparative pharmacogenetics of sparteine and debrisoquine.鹰爪豆碱和异喹胍的比较药物遗传学
Clin Pharmacol Ther. 1983 Mar;33(3):394-9. doi: 10.1038/clpt.1983.51.
6
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Acta Pharmacol Toxicol (Copenh). 1985 Nov;57(5):357-60. doi: 10.1111/j.1600-0773.1985.tb00058.x.
7
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.日本人群与白种人群之间在异喹胍和甲妥英羟基化遗传多态性上的种族差异。
Clin Pharmacol Ther. 1985 Oct;38(4):402-8. doi: 10.1038/clpt.1985.194.
8
Inter-ethnic difference in sparteine oxidation among Ghanaians and Germans.加纳人和德国人之间司巴丁氧化的种族间差异。
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9
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