Bagatin Ediléia, Gonçalves Heitor de Sá, Sato Maurício, Almeida Luiz Maurício Costa, Miot Helio Amante
Professor, Department of Dermatology, Federal University of São Paulo, SP, Brazil. Thesis advisor, Translational Medicine Post-Graduation Program, Federal University of São Paulo, São Paulo, Brazil.
Director, Dona Libânia Dermatology center, Department of Health, Ceará, Brazil.
Eur J Dermatol. 2018 Jun 1;28(3):343-350. doi: 10.1684/ejd.2018.3320.
Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging.
To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin.
MATERIALS & METHODS: An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0.3% gel or tretinoin 0.05% cream. Subjects were evaluated at Weeks 1, 4, 8, 12, 16, 20 and 24, based on clinical signs of cutaneous photoaging, histopathological and digital morphometric findings, as well as safety and tolerability.
A comparison of clinical efficacy showed that both treatments did not differ significantly regarding clinical evaluation of the following criteria: global cutaneous photoaging, periorbital wrinkles, ephelides/melanosis, forehead wrinkles, and AK.
Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.
既往已对阿达帕林作为光化性角化病（AK）和日光性雀斑样痣的治疗方法进行了评估，并显示其可改善光老化迹象。
评估0.3%阿达帕林凝胶作为光老化皮肤的治疗方法是否不劣于0.05%维甲酸乳膏。
在巴西进行了一项研究者设盲的平行组比较研究。受试者按1:1比例随机分组，每天接受一次0.3%阿达帕林凝胶或0.05%维甲酸乳膏治疗。根据皮肤光老化的临床体征、组织病理学和数字形态学结果以及安全性和耐受性，在第1、4、8、12、16、20和24周对受试者进行评估。
临床疗效比较表明，在以下标准的临床评估方面，两种治疗方法无显著差异：整体皮肤光老化、眶周皱纹、雀斑/黑素沉着、前额皱纹和AK。
0.3%阿达帕林凝胶作为光老化皮肤的治疗方法，疗效不劣于0.05%维甲酸乳膏，安全性相似。因此，0.3%阿达帕林凝胶可被视为治疗轻度或中度光老化的安全有效选择。
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