Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiangxi, Guangzhou, China.
Department of Clinical Laboratory, The People's Hospital of Zhuhai, Zhuhai, China.
Sci Rep. 2023 Sep 8;13(1):14855. doi: 10.1038/s41598-023-41949-x.
This study aims to reduce the cost of allergen testing for Guangzhou, China by limiting the number of allergens for which patients are tested, and provide a testing panel to improve diagnostic and therapeutic efficiency. This retrospective study of real-world data from 2012 to 2019 included 39,570 patients with suspected allergies in Guangzhou, southern China. All the patients were tested for one or more of the following allergens serum specific immunoglobulin E (sIgE): Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat dander, dog dander, Artemisia vulgaris, Aspergillus fumigatus, Alternaria alternata, Blattella germanica, egg whites, milk, wheat, peanuts, soybeans, Cancer pagurus, and Penaeus monodon by PhadiaCAP 1000. Totally, only the positive rates of allergens sIgE in D. farinae, D. pteronyssinus, milk, egg whites, B. germanica, C. pagurus, A. alternata, and P. monodon were > 10%, the other allergens were between 4-7%. Moreover, among the allergic diseases, dust mites exhibited the overall highest positive rate, followed by milk and B. germanica. In children, milk was the main allergen, whereas in adults, mites, cockroaches, shrimp, and crab allergens had higher positive rates. The optimal scale analysis shows that the multiple sensitization classification of patients can be divided into three categories: I D. farinae and D. pteronyssinus; II. C. pagurus, P. monodon, and B. germanica; III. Milk and egg whites. Generally, a panel including 4 allergens can detect > 90% of the potential allergy in this local population. In Guangzhou, southern China, D. farinae, milk, B. germanica, and A. alternata as a panel screening allergy for suspected allergic patients was suggested base on this study.
本研究旨在通过限制患者接受检测的过敏原数量来降低中国广州过敏原检测的成本，并提供一种检测面板以提高诊断和治疗效率。这是一项回顾性研究，纳入了 2012 年至 2019 年期间来自中国南方广州的 39570 名疑似过敏患者的真实世界数据。所有患者均接受了一种或多种过敏原血清特异性免疫球蛋白 E（sIgE）检测：屋尘螨、粉尘螨、猫皮屑、狗皮屑、蒿属花粉、烟曲霉、交链孢霉、德国小蠊、蛋清、牛奶、小麦、花生、大豆、中国对虾和中国明对虾，采用 PhadiaCAP 1000 进行检测。总的来说，仅屋尘螨、粉尘螨、牛奶、蛋清、德国小蠊、中国对虾、交链孢霉和中国明对虾的 sIgE 阳性率>10%，其他过敏原在 4-7%之间。此外，在过敏疾病中，尘螨的总体阳性率最高，其次是牛奶和德国小蠊。在儿童中，牛奶是主要过敏原，而在成人中，尘螨、蟑螂、虾和蟹过敏原的阳性率更高。最佳比例分析显示，患者的多重致敏分类可分为三类：I 型为屋尘螨和粉尘螨；II 型为中国对虾、中国明对虾和德国小蠊；III 型为牛奶和蛋清。一般来说，一个包含 4 种过敏原的面板可以检测到该地区潜在过敏人群中的>90%。本研究建议在中国南方广州，以屋尘螨、牛奶、德国小蠊和交链孢霉作为疑似过敏患者的面板筛查过敏。
