Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
BMC Ophthalmol. 2023 Sep 8;23(1):369. doi: 10.1186/s12886-023-03125-7.
To describe a case of orbital spindle cell carcinoma which presented with limbal ischemia and briefly review the literature.
Retrospective case report and brief literature review.
A 61-year old man presented with blepharoptosis, periorbital pain, decreased vision and limbal ischemia. He did not mention any previous illness and did not take any kind of drugs. Imaging revealed an orbital mass that was positive for SMA, Vimentin and CD99 and negative for S100. We treated the patient with chemotherapy and followed him for other complications that occurred throughout disease course.
Spindle cell carcinomas are a rare variant of squamous cell carcinoma (SCC) with dual malignant histologic differentiation of squamous and mesenchymal cells. Few cases of orbital spindle cell carcinoma have been reported, which have been either secondary to distant metastasis or regional spread. In this study, we have reported the first case of primary orbital spindle cell carcinoma presenting with limbal ischemia. Further studies are needed to describe the different clinical presentations and management strategies of this rare clinical entity.
描述一例表现为角膜缘缺血的眼眶梭形细胞癌，并简要复习文献。
回顾性病例报告及文献复习。
一名 61 岁男性因眼睑下垂、眶周疼痛、视力下降和角膜缘缺血就诊。他未提及任何既往病史，也未服用任何药物。影像学显示眶内肿块 SMA、波形蛋白和 CD99 阳性，S100 阴性。我们对患者进行了化疗，并对整个病程中出现的其他并发症进行了随访。
梭形细胞癌是一种罕见的鳞状细胞癌（SCC）变体，具有鳞状和间充质细胞的双重恶性组织学分化。报道的眼眶梭形细胞癌病例较少，要么是继发于远处转移，要么是局部扩散。在本研究中，我们报告了首例表现为角膜缘缺血的原发性眼眶梭形细胞癌。需要进一步的研究来描述这种罕见临床实体的不同临床表现和治疗策略。
