Alsalatie Mohammed, Alquran Hiam, Mustafa Wan Azani, Zyout Ala'a, Alqudah Ali Mohammad, Kaifi Reham, Qudsieh Suhair
King Hussein Medical Center, Royal Jordanian Medical Service, The Institute of Biomedical Technology, Amman 11855, Jordan.
Department of Biomedical Systems and Informatics Engineering, Yarmouk University, Irbid 21163, Jordan.
Diagnostics (Basel). 2023 Aug 25;13(17):2762. doi: 10.3390/diagnostics13172762.
One of the most widespread health issues affecting women is cervical cancer. Early detection of cervical cancer through improved screening strategies will reduce cervical cancer-related morbidity and mortality rates worldwide. Using a Pap smear image is a novel method for detecting cervical cancer. Previous studies have focused on whole Pap smear images or extracted nuclei to detect cervical cancer. In this paper, we compared three scenarios of the entire cell, cytoplasm region, or nucleus region only into seven classes of cervical cancer. After applying image augmentation to solve imbalanced data problems, automated features are extracted using three pre-trained convolutional neural networks: AlexNet, DarkNet 19, and NasNet. There are twenty-one features as a result of these scenario combinations. The most important features are split into ten features by the principal component analysis, which reduces the dimensionality. This study employs feature weighting to create an efficient computer-aided cervical cancer diagnosis system. The optimization procedure uses the new evolutionary algorithms known as Ant lion optimization (ALO) and particle swarm optimization (PSO). Finally, two types of machine learning algorithms, support vector machine classifier, and random forest classifier, have been used in this paper to perform classification jobs. With a 99.5% accuracy rate for seven classes using the PSO algorithm, the SVM classifier outperformed the RF, which had a 98.9% accuracy rate in the same region. Our outcome is superior to other studies that used seven classes because of this focus on the tissues rather than just the nucleus. This method will aid physicians in diagnosing precancerous and early-stage cervical cancer by depending on the tissues, rather than on the nucleus. The result can be enhanced using a significant amount of data.
影响女性的最普遍健康问题之一是宫颈癌。通过改进筛查策略早期发现宫颈癌将降低全球宫颈癌相关的发病率和死亡率。使用巴氏涂片图像是一种检测宫颈癌的新方法。先前的研究集中在整个巴氏涂片图像或提取的细胞核上来检测宫颈癌。在本文中,我们将整个细胞、细胞质区域或仅细胞核区域的三种情况与七种宫颈癌类别进行了比较。在应用图像增强来解决数据不平衡问题后,使用三个预训练的卷积神经网络:AlexNet、DarkNet 19和NasNet提取自动特征。这些情况组合产生了二十一个特征。通过主成分分析将最重要的特征分为十个特征,从而降低了维度。本研究采用特征加权来创建一个高效的计算机辅助宫颈癌诊断系统。优化过程使用了称为蚁狮优化(ALO)和粒子群优化(PSO)的新进化算法。最后,本文使用了两种机器学习算法,支持向量机分类器和随机森林分类器来执行分类任务。使用PSO算法对七种类别进行分类时,支持向量机分类器的准确率为99.5%,优于随机森林分类器,随机森林分类器在同一区域的准确率为98.9%。由于我们专注于组织而非仅仅细胞核,我们的结果优于其他使用七种类别的研究。这种方法将帮助医生根据组织而非细胞核来诊断癌前和早期宫颈癌。使用大量数据可以提高结果。