Faculty of Agricultural and Food Sciences, American University of Beirut, P.O. Box 11-0236, Beirut 1107, Lebanon.
Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236, Beirut 1107, Lebanon.
Int J Mol Sci. 2023 Aug 30;24(17):13440. doi: 10.3390/ijms241713440.
commonly known as grapevine is one of the most important fruit crops worldwide. Its cultivation started more than 7000 years ago in the Near East, and over the millennia was followed by the development of thousands of cultivars that were further selected and characterized for specific purposes. Its important pharmacological value and its richness in phytoconstituents were the triggers to perform this project. Seven extracts were prepared from five different varieties ( 'Black Pearl' (BP), 'Red Glob' (RG), 'Crimson' (CR), 'Beitamouni' (BE) and 'Superior' (SU)) by separating the pulp from the seeds, followed by methanolic extraction. The phytochemical analysis showed that red colored grapes (RE, BP and CR), the seeds from 'Black Pearl' and 'Red Globe' contain higher amounts of primary and secondary metabolites such as polyphenols, anthocyanins and reducing sugars. In addition to their richness in phytoconstituents, these varieties/seeds possess an important antioxidant activity. The results of the cell viability assays showed that the red varieties have a potential anticancer activity against Capan-2 pancreatic cancer and MDA-MB231(TNBC) breast cancer cell lines, with the greatest promise when combined with the seeds.
葡萄通常被称为是世界上最重要的水果作物之一。它的栽培始于 7000 多年前的近东地区，在几千年的时间里，发展出了数千个品种，这些品种进一步被选择和特化，以满足特定的目的。它重要的药理学价值和丰富的植物成分是进行这个项目的触发因素。从五个不同的品种（'黑珍珠'（BP）、'红全球'（RG）、'深红'（CR）、'Beitamouni'（BE）和'超级'（SU））中分离出果肉和种子，然后用甲醇提取，共制备了七种提取物。植物化学分析表明，红葡萄（RE、BP 和 CR）、'黑珍珠'和'红全球'的种子含有更多的初级和次级代谢产物，如多酚、花青素和还原糖。除了富含植物成分外，这些品种/种子还具有重要的抗氧化活性。细胞活力测定的结果表明，红葡萄品种对 Capan-2 胰腺癌细胞和 MDA-MB231（TNBC）乳腺癌细胞系具有潜在的抗癌活性，与种子联合使用时效果最好。
