Department of Physiology, University of Valencia, 46010 Valencia, Spain.
Biomedical Research Institute INCLIVA, University of Valencia, 46010 Valencia, Spain.
Int J Mol Sci. 2023 Aug 31;24(17):13537. doi: 10.3390/ijms241713537.
Activation of the aryl hydrocarbon receptor (AhR) has been shown to be important in physiological processes other than detoxification, including vascular homeostasis. Although AhR is highly expressed in the endothelium, its function has been poorly studied. This systematic review aims to summarise current knowledge on the AhR role in the endothelium and its cardiovascular implications. We focus on endogenous AhR agonists, such as some uremic toxins and other agonists unrelated to environmental pollutants, as well as studies using AhR knockout models. We conclude that AhR activation leads to vascular oxidative stress and endothelial dysfunction and that blocking AhR signalling could provide a new target for the treatment of vascular disorders such as cardiovascular complications in patients with chronic kidney disease or pulmonary arterial hypertension.
芳基烃受体 (AhR) 的激活除了解毒之外，在其他生理过程中也很重要，包括血管稳态。尽管 AhR 在血管内皮中高度表达，但对其功能的研究甚少。本系统综述旨在总结 AhR 在血管内皮中的作用及其心血管影响的现有知识。我们重点关注内源性 AhR 激动剂，如一些尿毒症毒素和与环境污染物无关的其他激动剂，以及使用 AhR 敲除模型的研究。我们得出结论，AhR 的激活导致血管氧化应激和内皮功能障碍，阻断 AhR 信号可能为治疗血管疾病提供一个新的靶点，如慢性肾脏病或肺动脉高压患者的心血管并发症。
