Renzelli Valerio, Gallo Marco, Morviducci Lelio, Marino Giampiero, Ragni Alberto, Tuveri Enzo, Faggiano Antongiulio, Mazzilli Rossella, Natalicchio Annalisa, Zatelli Maria Chiara, Montagnani Monica, Fogli Stefano, Giuffrida Dario, Argentiero Antonella, Danesi Romano, D'Oronzo Stella, Gori Stefania, Franchina Tindara, Russo Antonio, Monami Matteo, Sciacca Laura, Cinieri Saverio, Colao Annamaria, Avogaro Angelo, Di Cianni Graziano, Giorgino Francesco, Silvestris Nicola
Italian Association of Clinical Diabetologists, 00192 Rome, Italy.
Endocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, Italy.
Cancers (Basel). 2023 Aug 24;15(17):4237. doi: 10.3390/cancers15174237.
There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.
越来越多的证据表明，用于制造和加工的常用化合物衍生的内分泌干扰物（EDs）在改变激素信号传导和功能方面发挥着作用。由于其半衰期长且具有持久性，EDs通常不仅存在于工业产品中，还存在于家庭和环境中，为长期接触创造了条件。多溴二苯醚（PBDEs）是工业产品（如阻燃剂）中常用的EDs，最近的研究越来越多地表明它们可能干扰代谢和致癌途径。在本文中，由意大利医学糖尿病学家协会（AMD）、意大利糖尿病学会（SID）、意大利医学肿瘤学协会（AIOM）、意大利内分泌学会（SIE）和意大利药理学会（SIF）的多学科专家小组对PBDEs在人类健康和疾病中的潜在作用进行了综述，探讨了分子和临床方面，并重点关注代谢和致癌途径。
