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基于深度学习的乳腺癌病理图像分割。

Breast Cancer Histopathological Images Segmentation Using Deep Learning.

机构信息

Laboratoire SIMPA, Département d'Informatique, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf (USTO-MB), Oran 31000, Algeria.

Centre de Recherche en Informatique de Lens, CRIL, CNRS, Université d'Artois, 62307 Lens, France.

出版信息

Sensors (Basel). 2023 Aug 22;23(17):7318. doi: 10.3390/s23177318.

DOI:10.3390/s23177318
PMID:37687772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10490494/
Abstract

Hospitals generate a significant amount of medical data every day, which constitute a very rich database for research. Today, this database is still not exploitable because to make its valorization possible, the images require an annotation which remains a costly and difficult task. Thus, the use of an unsupervised segmentation method could facilitate the process. In this article, we propose two approaches for the semantic segmentation of breast cancer histopathology images. On the one hand, an autoencoder architecture for unsupervised segmentation is proposed, and on the other hand, an improvement U-Net architecture for supervised segmentation is proposed. We evaluate these models on a public dataset of histological images of breast cancer. In addition, the performance of our segmentation methods is measured using several evaluation metrics such as accuracy, recall, precision and F1 score. The results are competitive with those of other modern methods.

摘要

医院每天产生大量的医疗数据,这些数据构成了一个非常丰富的研究数据库。如今,这个数据库仍然无法被利用,因为要使其具有价值,这些图像需要进行注释,而注释仍然是一项昂贵且困难的任务。因此,使用无监督分割方法可以简化这个过程。在本文中,我们提出了两种用于乳腺癌组织病理学图像语义分割的方法。一方面,我们提出了一种用于无监督分割的自动编码器架构,另一方面,我们提出了一种用于监督分割的 U-Net 架构的改进方法。我们在一个公共的乳腺癌组织学图像数据集上评估了这些模型。此外,我们使用多种评估指标(如准确性、召回率、精度和 F1 分数)来衡量我们分割方法的性能。我们的结果与其他现代方法的结果相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/bf0a4343b90f/sensors-23-07318-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/82f0a7a7c179/sensors-23-07318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/604e640b304c/sensors-23-07318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/b74288145780/sensors-23-07318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/4b13a0e766b5/sensors-23-07318-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/bf0a4343b90f/sensors-23-07318-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/82f0a7a7c179/sensors-23-07318-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/604e640b304c/sensors-23-07318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/b74288145780/sensors-23-07318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/4b13a0e766b5/sensors-23-07318-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a9f/10490494/bf0a4343b90f/sensors-23-07318-g007.jpg

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本文引用的文献

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Clin Breast Cancer. 2022 Oct;22(7):e818-e824. doi: 10.1016/j.clbc.2022.06.003. Epub 2022 Jun 29.
2
Boundary-rendering network for breast lesion segmentation in ultrasound images.用于超声图像中乳腺病变分割的边界渲染网络。
Med Image Anal. 2022 Aug;80:102478. doi: 10.1016/j.media.2022.102478. Epub 2022 Jun 5.
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Breast nodule classification with two-dimensional ultrasound using Mask-RCNN ensemble aggregation.
HI-Net:一种通过轻量级数据集构建用于转移性乳腺癌的新型组织病理学图像分割模型。
Heliyon. 2024 Sep 27;10(19):e38410. doi: 10.1016/j.heliyon.2024.e38410. eCollection 2024 Oct 15.
基于 Mask-RCNN 集成聚合的二维超声乳腺结节分类。
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An unsupervised method for histological image segmentation based on tissue cluster level graph cut.基于组织簇级图割的无监督组织学图像分割方法。
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Convolutional Neural Network of Multiparametric MRI Accurately Detects Axillary Lymph Node Metastasis in Breast Cancer Patients With Pre Neoadjuvant Chemotherapy.卷积神经网络多参数 MRI 术前新辅助化疗后准确检测乳腺癌患者腋窝淋巴结转移
Clin Breast Cancer. 2022 Feb;22(2):170-177. doi: 10.1016/j.clbc.2021.07.002. Epub 2021 Jul 13.
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A review and comparison of breast tumor cell nuclei segmentation performances using deep convolutional neural networks.基于深度卷积神经网络的乳腺肿瘤细胞细胞核分割性能的评估与比较。
Sci Rep. 2021 Apr 13;11(1):8025. doi: 10.1038/s41598-021-87496-1.
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A multi-phase deep CNN based mitosis detection framework for breast cancer histopathological images.基于多阶段深度卷积神经网络的乳腺癌病理图像有丝分裂检测框架。
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