Li Yutong, Qi Ruilian, Wang Xiaoyu, Yuan Huanxiang
Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Polymers (Basel). 2023 Aug 28;15(17):3570. doi: 10.3390/polym15173570.
The infectious diseases resulting from pathogenic microbes are highly contagious and the source of infection is difficult to control, which seriously endangers life and public health safety. Although the emergence of antibiotics has a good therapeutic effect in the early stage, the massive abuse of antibiotics has brought about the evolution of pathogens with drug resistance, which has gradually weakened the lethality and availability of antibiotics. Cancer is a more serious disease than pathogenic bacteria infection, which also threatens human life and health. Traditional treatment methods have limitations such as easy recurrence, poor prognosis, many side effects, and high toxicity. These two issues have led to the exploration and development of novel therapeutic agents (such as conjugated polymers) and therapeutic strategies (such as phototherapy) to avoid the increase of drug resistance and toxic side effects. As a class of organic polymer biological functional materials with excellent photoelectric properties, Conjugated polymers (CPs) have been extensively investigated in biomedical fields, such as the detection and treatment of pathogens and tumors due to their advantages of easy modification and functionalization, good biocompatibility and low cost. A rare comprehensive overview of CPs-based detection and treatment applications has been reported. This paper reviews the design strategies and research status of CPs used in biomedicine in recent years, introduces and discusses the latest progress of their application in the detection and treatment of pathogenic microorganisms and tumors according to different detection or treatment methods, as well as the limitations and potential challenges in prospective exploration.
由致病微生物引起的传染病具有高度传染性，且感染源难以控制，严重危及生命和公共卫生安全。尽管抗生素在早期出现时具有良好的治疗效果，但抗生素的大量滥用导致了具有耐药性的病原体的进化，逐渐削弱了抗生素的杀伤力和可用性。癌症是一种比病原菌感染更严重的疾病，也威胁着人类的生命和健康。传统治疗方法存在易复发、预后差、副作用多、毒性高等局限性。这两个问题促使人们探索和开发新型治疗剂（如共轭聚合物）和治疗策略（如光疗），以避免耐药性增加和毒副作用。共轭聚合物（CPs）作为一类具有优异光电性能的有机聚合物生物功能材料，因其易于修饰和功能化、生物相容性好、成本低等优点，在生物医学领域如病原菌和肿瘤的检测与治疗方面受到了广泛研究。目前尚未见关于基于CPs的检测和治疗应用的罕见综合综述报道。本文综述了近年来用于生物医学的CPs的设计策略和研究现状，根据不同的检测或治疗方法介绍并讨论了其在致病微生物和肿瘤检测与治疗中的最新进展，以及前瞻性探索中的局限性和潜在挑战。
