Li Jiangao, Kang Miaomiao, Zhang Zhijun, Li Xue, Xu Weilin, Wang Dong, Gao Xike, Tang Ben Zhong
Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
China Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
Angew Chem Int Ed Engl. 2023 May 8;62(20):e202301617. doi: 10.1002/anie.202301617. Epub 2023 Apr 12.
Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual-acceptor engineering strategy is exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featuring different electronic affinity and π-conjugation degrees, and making full use of the active intramolecular motion-induced photothermal effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, an extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser-excited photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination.
将超长激发波长、高消光系数和卓越的光热转换能力整合到单一光热剂中是一项颇具吸引力但极具挑战性的任务。在此，基于供体-受体（D-A）型半导体聚合物，通过巧妙调节两种具有不同电子亲和力和π共轭程度的电子受体部分的摩尔比例，并充分利用分子内活性运动诱导的光热效应，开发了一种精确的双受体工程策略用于此尝试。最优聚合物SP4同时展现出理想的第二近红外（NIR-II）吸收、极高的消光系数和令人满意的光热转换行为。因此，通过精确的肿瘤诊断和肿瘤完全消除，证明了SP4纳米颗粒在1064 nm激光激发的光声成像（PAI）引导的光热疗法（PTT）方面具有前所未有的性能。
