Reed John H, Seebeck Florian P
Department of Chemistry, University of Basel, Mattenstrasse 24a, 4002, Basel, Switzerland.
Molecular Systems Engineering, National Competence Center in Research, 4058, Basel, Switzerland.
Angew Chem Int Ed Engl. 2024 Feb 12;63(7):e202311159. doi: 10.1002/anie.202311159. Epub 2023 Nov 6.
Biocatalysis has become a major driver in the innovation of preparative chemistry. Enzyme discovery, engineering and computational design have matured to reliable strategies in the development of biocatalytic processes. By comparison, substrate engineering has received much less attention. In this Minireview, we highlight the idea that the design of synthetic reagents may be an equally fruitful and complementary approach to develop novel enzyme-catalysed group transfer chemistry. This Minireview discusses key examples from the literature that illustrate how synthetic substrates can be devised to improve the efficiency, scalability and sustainability, as well as the scope of such reactions. We also provide an opinion as to how this concept might be further developed in the future, aspiring to replicate the evolutionary success story of natural group transfer reagents, such as adenosine triphosphate (ATP) and S-adenosyl methionine (SAM).
生物催化已成为制备化学创新的主要驱动力。酶的发现、工程改造和计算设计已发展成为生物催化过程开发中可靠的策略。相比之下，底物工程受到的关注要少得多。在这篇微型综述中，我们强调这样一种观点，即合成试剂的设计可能是开发新型酶催化基团转移化学的一种同样富有成效且互补的方法。这篇微型综述讨论了文献中的关键例子，这些例子说明了如何设计合成底物以提高此类反应的效率、可扩展性和可持续性，以及反应范围。我们还就这一概念未来如何进一步发展提出了看法，期望复制天然基团转移试剂（如三磷酸腺苷（ATP）和S-腺苷甲硫氨酸（SAM））的进化成功故事。
