Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Int Immunopharmacol. 2023 Nov;124(Pt A):110436. doi: 10.1016/j.intimp.2023.110436. Epub 2023 Sep 7.
Neutrophils release neutrophil extracellular traps (NETs) to trap pathogenic microorganisms. NETs are involved in the inflammatory response and bacterial killing and clearance. However, their excessive activation can lead to an inflammatory storm in the body, which may damage tissues and cause organ dysfunction. Organ dysfunction is the main pathophysiological cause of sepsis and also a cause of the high mortality rate in sepsis. Acute lung injury caused by sepsis accounts for the highest proportion of organ damage in sepsis. NET formation can lead to the development of sepsis because by promoting the release of interleukin-1 beta, interleukin-8, and tumor necrosis factor-alpha, thereby accelerating acute lung injury. In this review, we describe the critical role of NETs in sepsis-associated acute lung injury and review the current knowledge and novel therapeutic approaches.
中性粒细胞释放中性粒细胞胞外诱捕网（NETs）以捕获致病微生物。NETs 参与炎症反应和细菌杀伤及清除。然而，其过度激活可导致体内炎症风暴，从而可能损伤组织并导致器官功能障碍。器官功能障碍是脓毒症的主要病理生理原因，也是脓毒症高死亡率的原因之一。脓毒症引起的急性肺损伤在脓毒症器官损伤中占比最高。NET 形成可导致脓毒症的发生，因为其可促进白细胞介素-1β、白细胞介素-8 和肿瘤坏死因子-α的释放，从而加速急性肺损伤。在本综述中，我们描述了 NETs 在脓毒症相关急性肺损伤中的关键作用，并回顾了目前的知识和新的治疗方法。
