Josephson G W, MacKenzie E J, Lietman P S, Gibson G
JAMA. 1979 Aug 17;242(7):639-43.
The effectiveness of epinephrine was compared to that of a combination of epinephrine and aminophylline in the initial treatment of acute asthma. Forty-four patients with 51 episodes of acute asthma were evaluated. Peak flow spirometry served as an objective measure of airway resistance, and theophylline levels were determined at fixed intervals throughout the study. Epinephrine and aminophylline were not found to be superior to epinephrine alone. There was no correlation between mean serum theophylline levels and the magnitude of improvement. Rapidity of emergency department discharge and frequency of admission was independent of treatment method. The failure of epinephrine-aminophylline to effect more rapid or profound improvement in pulmonary function might suggest that epinephrine alone, or an equivalent sympathomimetic is a rational choice in the initial treatment of acute asthma.
在急性哮喘的初始治疗中，将肾上腺素的疗效与肾上腺素和氨茶碱联合使用的疗效进行了比较。对44例患者的51次急性哮喘发作进行了评估。峰值流速肺活量测定法作为气道阻力的客观测量方法，在整个研究过程中定期测定茶碱水平。未发现肾上腺素和氨茶碱联合使用比单独使用肾上腺素更具优势。平均血清茶碱水平与改善程度之间没有相关性。急诊科出院的速度和入院频率与治疗方法无关。肾上腺素-氨茶碱未能使肺功能更快或更显著改善，这可能表明在急性哮喘的初始治疗中，单独使用肾上腺素或等效的拟交感神经药是合理的选择。
