Oxford Centre for Computational Neuroscience, Oxford, United Kingdom.
Department of Computer Science, University of Warwick, Coventry CV4 7AL, United Kingdom.
Cereb Cortex. 2023 Oct 9;33(20):10686-10701. doi: 10.1093/cercor/bhad318.
The hierarchical organization between 25 ventral stream visual cortical regions and 180 cortical regions was measured with magnetoencephalography using the Human Connectome Project Multimodal Parcellation atlas in 83 Human Connectome Project participants performing a visual memory task. The aim was to reveal the hierarchical organization using a whole-brain model based on generative effective connectivity with this fast neuroimaging method. V1-V4 formed a first group of interconnected regions. Especially V4 had connectivity to a ventrolateral visual stream: V8, the fusiform face cortex, and posterior inferior temporal cortex PIT. These regions in turn had effectivity connectivity to inferior temporal cortex visual regions TE2p and TE1p. TE2p and TE1p then have connectivity to anterior temporal lobe regions TE1a, TE1m, TE2a, and TGv, which are multimodal. In a ventromedial visual stream, V1-V4 connect to ventromedial regions VMV1-3 and VVC. VMV1-3 and VVC connect to the medial parahippocampal gyrus PHA1-3, which, with the VMV regions, include the parahippocampal scene area. The medial parahippocampal PHA1-3 regions have connectivity to the hippocampal system regions the perirhinal cortex, entorhinal cortex, and hippocampus. These effective connectivities of two ventral visual cortical streams measured with magnetoencephalography provide support to the hierarchical organization of brain systems measured with fMRI, and new evidence on directionality.
使用磁共振成像技术，通过人类连接组计划多模态分区图谱，在 83 名执行视觉记忆任务的人类连接组计划参与者中，测量了 25 个腹侧流视觉皮质区域和 180 个皮质区域之间的层次组织。目的是使用基于生成有效连通性的全脑模型，通过这种快速的神经影像学方法揭示层次组织。V1-V4 形成了第一个相互连接的区域。特别是 V4 与腹侧视觉流有连通性：V8、梭状回面孔区和颞下回后极 PIT。这些区域反过来又与颞下回视觉区域 TE2p 和 TE1p 有有效性连接。TE2p 和 TE1p 然后与颞上回区域 TE1a、TE1m、TE2a 和 TGv 有连接，这些区域是多模态的。在腹侧视觉流中，V1-V4 与腹侧区域 VMV1-3 和 VVC 相连。VMV1-3 和 VVC 与内侧旁海马回 PHA1-3 相连，VMV 区域和 PHA1-3 区域包括旁海马场景区。内侧旁海马回 PHA1-3 区域与边缘叶系统的内嗅皮层、内颞叶皮层和海马体有连接。这些通过磁共振成像测量的两个腹侧视觉皮质流的有效连通性为通过 fMRI 测量的大脑系统的层次组织提供了支持，并提供了关于方向性的新证据。
