Department of Computer Science, University of Warwick, Coventry, UK.
Institute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
Hum Brain Mapp. 2024 Oct 15;45(15):e70056. doi: 10.1002/hbm.70056.
Different cortical systems to the hippocampus were activated using fMRI during different types of episodic memory task. For object with scene location episodic memory, the activations were high in cortical systems involved in spatial processing, including the ventromedial visual and medial parahippocampal system. These activations for the medial parahippocampal system were higher in the right hemisphere. The activations in the face and object processing ventrolateral visual cortical stream regions FFC, PIT, V8 and TE2p were higher in the object-location in scene task than the reward-location task, and were higher in the right hemisphere. For reward-location in scene episodic memory, activations were also high in the ventromedial visual cortical spatial stream to the hippocampus, but were also selectively high in storage in key reward cortical regions (ventromedial prefrontal 10r, 10v, 10d; pregenual anterior cingulate d32, p24, p32, s32; and medial orbitofrontal cortex reward-related pOFC, 11l, OFC). For word-pair episodic memory, activations were lower in the ventromedial visual and medial parahippocampal spatial cortical stream, and were higher in language-related regions in Broca's area (44, 45, 47l), and were higher in the left hemisphere for these regions and for the many highly connected inferior frontal gyrus regions in the left hemisphere. Further, effective connectivity analyses during the episodic memory tasks showed that the direction of connectivity for these systems was from early visual cortical regions V2-V4 to the ventromedial visual cortical regions VMV1-3 and VVC for spatial scene processing; was from the pregenual anterior cingulate and orbitofrontal cortex reward systems to the hippocampal system; and was from the FFC/V8/PIT system to TE2p in the visual inferior temporal visual cortex, which has connectivity to lateral parahippocampal TF, which in turn has forward effective connectivity to the hippocampus.
在不同类型的情景记忆任务中，使用 fMRI 激活了不同的皮质系统到海马体。对于带有场景位置情节记忆的物体，在涉及空间处理的皮质系统中激活较高，包括腹侧视觉和内侧海马旁系统。右半球的内侧海马旁系统的这些激活更高。在物体-位置场景任务中，外侧视皮质流区 FFC、PIT、V8 和 TE2p 的面部和物体处理激活更高，而在奖励-位置任务中则较低，且在右半球更高。对于情景记忆中的奖励-位置，腹侧视觉皮质空间流到海马体的激活也较高，但在关键奖励皮质区域（腹侧前额叶 10r、10v、10d；前扣带回 d32、p24、p32、s32；内侧眶额皮层奖励相关 pOFC、11l、OFC）的存储中也选择性地较高。对于词对情节记忆，腹侧视觉和内侧海马旁空间皮质流的激活较低，而在布罗卡区的语言相关区域（44、45、47l）较高，这些区域以及左侧许多高度连接的额下回区域的激活更高。此外，在情景记忆任务期间的有效连接分析表明，这些系统的连接方向是从早期视觉皮质区域 V2-V4 到腹侧视觉皮质区域 VMV1-3 和 VVC 进行空间场景处理；从前扣带和眶额皮层奖励系统到海马体系统；从 FFC/V8/PIT 系统到视觉下颞叶视觉皮质的 TE2p，该区域与外侧海马旁 TF 有连接，而后者与海马体有向前的有效连接。
