National Engineering Research Center for Modernization of Traditional Chinese Medicine - Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China.
Broad-Ocean Bio-Science and Technique Co., Ltd. of Changsha, Changsha, China.
Nat Prod Res. 2024 Oct;38(20):3574-3580. doi: 10.1080/14786419.2023.2256446. Epub 2023 Sep 10.
The phytochemical investigation on the rhizomes of (Dryopteridaceae) resulted in the discovery of one novel compound, drycrassirhizomamide A (), and one new natural product, drycrassirhizomamide B (), as well as four known isolates, ()-(-)--benzoylphenylalaninol (), blumenol A (), 8--glucosylnoreugenin (), and dryopteroside (). Their chemical structures were identified by NMR and mass spectroscopy. Compounds were determined to be 1,19-diethyl 10-oxo-2,9,11,18-tetraazanonadecanedioate and ,'-diethyl ,'-1,6-hexanediylbis[carbamate]. The anti-inflammatory activities of these compounds were evaluated with LPS-stimulated RAW264.7 macrophage and BV2 microglia. The results showed that compounds and have inhibitory effects of NO production with IC values of 13.41, 30.36, 25.51, and 11.35 μM in LPS-stimulated RAW264.7 cells. Also, compounds and have abilities to inhibit NO production with the IC values of 40.11, 30.94, 15.76, and 16.79 μM in BV2 cells, which demonstrated that they may possess the potential anti-inflammatory activity.
从（鳞毛蕨科）的根茎中进行植物化学研究，发现了一种新化合物，干燥粗根酰胺 A（），和一种新的天然产物，干燥粗根酰胺 B（），以及四个已知的分离物，（）-（-）-苯甲酰基苯丙氨酸醇（）， blumenol A（），8--葡萄糖基诺瑞吉宁（）和 dryopteroside（）。它们的化学结构通过 NMR 和质谱鉴定。化合物和被确定为 1,19-二乙基 10-氧代-2,9,11,18-四氮杂十一烷二酸酯和，'-二乙基，'-1,6-己二基双[氨基甲酸酯]。这些化合物的抗炎活性通过 LPS 刺激的 RAW264.7 巨噬细胞和 BV2 小胶质细胞进行评估。结果表明，化合物和在 LPS 刺激的 RAW264.7 细胞中具有抑制 NO 产生的作用，IC 值分别为 13.41、30.36、25.51 和 11.35 μM。此外，化合物和在 BV2 细胞中具有抑制 NO 产生的能力，IC 值分别为 40.11、30.94、15.76 和 16.79 μM，表明它们可能具有潜在的抗炎活性。
