Wu Jiwei, Zhang Yuting, Yang Jingyi, Yu Lingxiang, Zhang Shaoqing, Zhou Jie, Li Zirong, Xu Xiaolan, Xu Huajian
College of Chemistry and Materials Engineering, Anhui Science and Technology University, Fengyang, 233100, P. R. China.
School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Institute of Industry & Equipment Technology, Hefei University of Technology, Hefei, 230009, P. R. China.
J Org Chem. 2023 Oct 6;88(19):13590-13597. doi: 10.1021/acs.joc.3c01270. Epub 2023 Sep 10.
A novel method for the synthesis of formamides through the decarboxylative -formylation of amines with glyoxylic acid has been developed. This transformation provides an efficient protocol for the synthesis of various formamides with moderate to excellent yields, and it can accommodate a wide range of functional groups under metal free and base free conditions. In addition, the large-scale experiments and high chemoselectivity have shown great potential application of this strategy.
已开发出一种通过胺与乙醛酸的脱羧甲酰化反应合成甲酰胺的新方法。该转化反应为合成各种甲酰胺提供了一种高效方案，产率适中至优异，并且在无金属和无碱条件下可兼容多种官能团。此外，大规模实验和高化学选择性表明了该策略具有巨大的潜在应用价值。
