圭亚那锡帕鲁纳精油对艾氏模型的抗肿瘤活性及其对氧化应激的影响。

Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress.

作者信息

Viana Barbosa Lucas Gabriel, Silva de Jesus Ellen Nayara, Botelho Jerônimo Lucas, Silva da Costa Jamile, Cunha Silva Renata, Setzer William N, R da Silva Joyce Kelly, da Silva Freitas Jofre Jacob, B Figueiredo Pablo Luis

机构信息

Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, 66087-662, Brazil.

Laboratório de Morfofisiologia Aplicada a Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, 66087-662, Brazil.

出版信息

Chem Biodivers. 2023 Oct;20(10):e202301120. doi: 10.1002/cbdv.202301120. Epub 2023 Sep 21.

DOI:10.1002/cbdv.202301120

PMID:37691004

Abstract

This work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5 %), drimenol (13.7±0.2 %), and spathulenol (12.4±0.8 %). S. guianensis oil showed antioxidant activity, inhibiting 11.1 % of DPPH radicals (95.7 mgTE/g); and 15.5 % of the β-carotene peroxidation. The group treated with S. guianensis showed a significant reduction in tumor cells (59.76±12.33) compared to the tumor group (96.88±19.15). Essential oil of S. guianensis decreased MDA levels and increased SOD levels in liver tissue. The essential oil of S. guianensis reduced oxidative stress, and showed antitumor and antioxidant activity, being characterized as a new chemical profile in the investigation of pathologies such as cancer.

摘要

本研究旨在评估圭亚那砂仁精油的化学成分、体外抗氧化能力及对艾氏腹水癌的体内抗肿瘤活性，以及其对氧化应激的影响。实验动物（小家鼠）每日口服剂量为100 mg/kg的圭亚那砂仁精油，连续给药9天。该精油的主要成分包括莪术烯酮（16.4±1.5%）、白菖烯醇（13.7±0.2%）和匙叶桉油烯醇（12.4±0.8%）。圭亚那砂仁精油具有抗氧化活性，可抑制11.1%的DPPH自由基（95.7 mgTE/g），并抑制15.5%的β-胡萝卜素过氧化反应。与肿瘤组（96.88±19.15）相比，接受圭亚那砂仁精油治疗的组肿瘤细胞显著减少（59.76±12.33）。圭亚那砂仁精油可降低肝脏组织中的丙二醛水平，并提高超氧化物歧化酶水平。圭亚那砂仁精油可减轻氧化应激，具有抗肿瘤和抗氧化活性，在癌症等疾病的研究中表现出一种新的化学特征。