Quazi Sameer
GenLab Biosolutions Private Limited, Bangalore, Karnataka, India.
Department of Biomedical Sciences, School of Life Sciences, Anglia Ruskin University, Anglia, United Kingdom.
Front Bioeng Biotechnol. 2023 Aug 24;11:1193493. doi: 10.3389/fbioe.2023.1193493. eCollection 2023.
The deadliest disease in the world, cancer, kills many people every year. The early detection is the only hope for the survival of malignant cancer patients. As a result, in the preliminary stages of, the diagnosis of cancer biomarkers at the cellular level is critical for improving cancer patient survival rates. For decades, scientists have focused their efforts on the invention of biosensors. Biosensors, in addition to being employed in other practical scenarios, can essentially function as cost effective and highly efficient devices for this purpose. Traditional cancer screening procedures are expensive, time-consuming, and inconvenient for repeat screenings. Biomarker-based cancer diagnosis, on the other hand, is rising as one of the most potential tools for early detection, disease progression monitoring, and eventual cancer treatment. As Biosensor is an analytical device, it allows the selected analyte to bind to the biomolecules being studied (for example RNA, DNA, tissue, proteins, and cells). They can be divided based on the kind of biorecognition or transducer elements on the sensor. Most biosensor analyses necessitate the analyte being labeled with a specific marker. In this review article, the application of distinct variants of biosensors against cancer has been described.
癌症是世界上最致命的疾病，每年都有许多人死于癌症。早期检测是恶性癌症患者生存的唯一希望。因此，在癌症的初步阶段，在细胞水平上诊断癌症生物标志物对于提高癌症患者的生存率至关重要。几十年来，科学家们一直致力于生物传感器的发明。生物传感器除了应用于其他实际场景外，本质上还可以作为实现这一目的的经济高效设备。传统的癌症筛查程序昂贵、耗时，且不方便进行重复筛查。另一方面，基于生物标志物的癌症诊断正成为早期检测、疾病进展监测以及最终癌症治疗最具潜力的工具之一。由于生物传感器是一种分析设备，它能使选定的分析物与正在研究的生物分子（如RNA、DNA、组织、蛋白质和细胞）结合。它们可以根据传感器上生物识别或换能元件的类型进行划分。大多数生物传感器分析需要用特定标记物对分析物进行标记。在这篇综述文章中，已经描述了不同类型的生物传感器在对抗癌症方面的应用。
