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整形手术与美容医学中的干细胞

Stem cells in plastic surgery and aesthetic medicine.

作者信息

Czop Julia Katarzyna, Jałowska Magdalena

机构信息

Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Postepy Dermatol Alergol. 2023 Aug;40(4):504-509. doi: 10.5114/ada.2023.130498. Epub 2023 Sep 1.

DOI:10.5114/ada.2023.130498
PMID:37692263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485752/
Abstract

Stem cells (SCs) have multiple applications in today's medicine including aesthetic dermatology and plastic surgery. The purpose of this paper is to review some clinical use of mesenchymal SCs. The main focus was put on adipose tissue-derived stem cells (ADSCs) as these cells are easy to harvest and because of their properties showed great potential in many studies, where they proved to accelerate wound healing, reduce scars, cause hair regrowth, or rejuvenate skin. Furthermore, when added to lipofilling procedures, such as breast augmentation they enhance fat graft survival and provide satisfying results. Currently, many different strategies for using SCs in treatments are developed with great efficacy, however, there are still many limitations and concerns regarding their clinical use.

摘要

干细胞在当今医学中有多种应用,包括美容皮肤科和整形手术。本文的目的是综述间充质干细胞的一些临床应用。主要关注的是脂肪组织来源的干细胞(ADSCs),因为这些细胞易于获取,并且由于其特性在许多研究中显示出巨大潜力,在这些研究中它们被证明可以加速伤口愈合、减少疤痕、促进头发生长或使皮肤恢复活力。此外,当添加到脂肪填充手术(如隆胸)中时,它们可提高脂肪移植的存活率并提供令人满意的效果。目前,已开发出许多在治疗中使用干细胞的不同策略,且疗效显著,然而,关于它们的临床应用仍存在许多限制和担忧。

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1
Stem cells in plastic surgery and aesthetic medicine.整形手术与美容医学中的干细胞
Postepy Dermatol Alergol. 2023 Aug;40(4):504-509. doi: 10.5114/ada.2023.130498. Epub 2023 Sep 1.
2
A Comparative Analysis of the Advances in Stem Cell Therapy in Plastic Surgery: A Systematic Review of Current Applications and Future Directions.整形手术中干细胞治疗进展的比较分析:当前应用及未来方向的系统评价
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Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation.脂肪来源的细胞和细胞衍生的再生疗法在皮肤科和美容年轻化中的应用。
Ageing Res Rev. 2019 Sep;54:100933. doi: 10.1016/j.arr.2019.100933. Epub 2019 Jun 24.
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Research update of adipose tissue-based therapies in regenerative dermatology.脂肪组织疗法在再生皮肤学中的研究进展。
Stem Cell Rev Rep. 2022 Aug;18(6):1956-1973. doi: 10.1007/s12015-022-10328-w. Epub 2022 Mar 1.
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Importance of mesenchymal stem cells in autologous fat grafting: a systematic review of existing studies.间充质干细胞在自体脂肪移植中的重要性:现有研究的系统评价
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Clinical applications of mesenchymal stem cells in soft tissue augmentation.间充质干细胞在软组织填充中的临床应用。
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本文引用的文献

1
Histological analysis of fat grafting with platelet-rich plasma for diabetic foot ulcers-A randomised controlled trial.富血小板血浆脂肪移植治疗糖尿病足溃疡的组织学分析:一项随机对照试验。
Int Wound J. 2022 Feb;19(2):389-398. doi: 10.1111/iwj.13640. Epub 2021 Jun 24.
2
Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells: Three case reports and review of literature.使用微操作的人脐带间充质干细胞治疗脱发:三例病例报告及文献综述
World J Clin Cases. 2021 May 26;9(15):3741-3751. doi: 10.12998/wjcc.v9.i15.3741.
3
Exosomes from adipose-derived stem cells and application to skin wound healing.脂肪来源干细胞来源的外泌体及其在皮肤创伤愈合中的应用。
Cell Prolif. 2021 Mar;54(3):e12993. doi: 10.1111/cpr.12993. Epub 2021 Jan 17.
4
Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation.脂肪组织源性干细胞在乳房重建中的应用:生物学特性与临床转化研究进展。
Stem Cell Res Ther. 2021 Jan 6;12(1):8. doi: 10.1186/s13287-020-01955-6.
5
Ex vivo-expanded autologous adipose tissue-derived stromal cells ensure enhanced fat graft retention in breast augmentation: A randomized controlled clinical trial.体外扩增自体脂肪组织来源的基质细胞可确保乳房增大中脂肪移植物的保留率提高:一项随机对照临床试验。
Stem Cells Transl Med. 2020 Nov;9(11):1277-1286. doi: 10.1002/sctm.20-0081. Epub 2020 Jul 8.
6
Efficacy and safety of umbilical cord mesenchymal stem cells in treatment of cesarean section skin scars: a randomized clinical trial.脐带间充质干细胞治疗剖宫产术后皮肤瘢痕的疗效和安全性:一项随机临床试验。
Stem Cell Res Ther. 2020 Jun 25;11(1):244. doi: 10.1186/s13287-020-01695-7.
7
Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double-blind, placebo-controlled trial.培洛昔福动员干细胞治疗糖尿病缺血性创面愈合:一项 IIa 期、随机、双盲、安慰剂对照试验。
Stem Cells Transl Med. 2020 Sep;9(9):965-973. doi: 10.1002/sctm.20-0020. Epub 2020 Jun 2.
8
A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia.一项使用脂肪来源干细胞成分提取物治疗雄激素性脱发的随机、双盲、对照的临床研究。
Stem Cells Transl Med. 2020 Aug;9(8):839-849. doi: 10.1002/sctm.19-0410. Epub 2020 May 18.
9
Autologous fat graft assisted by stromal vascular fraction improves facial skin quality: A randomized controlled trial.基质血管成分辅助自体脂肪移植改善面部皮肤质量:一项随机对照试验。
J Plast Reconstr Aesthet Surg. 2020 Jun;73(6):1166-1173. doi: 10.1016/j.bjps.2019.11.010. Epub 2019 Nov 29.
10
Microfat and Nanofat: When and Where These Treatments Work.微脂肪和纳米脂肪:这些治疗方法的适用时机和部位
Facial Plast Surg Clin North Am. 2019 Aug;27(3):321-330. doi: 10.1016/j.fsc.2019.03.004.