Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, China.
Department of Radiation Therapy, Zhejiang Cancer Hospital, Hangzhou, China.
Stem Cell Res Ther. 2021 Jan 6;12(1):8. doi: 10.1186/s13287-020-01955-6.
Recent developments in adipose-derived stromal/stem cell (ADSC) biology provide new hopes for tissue engineering and regeneration medicine. Due to their pluripotent activity, paracrine activity, and immunomodulatory function, ADSCs have been widely administrated and exhibited significant therapeutic effects in the treatment for autoimmune disorders, neurodegenerative diseases, and ischemic conditions both in animals and human clinical trials. Cell-assisted lipotransfer (CAL) based on ADSCs has emerged as a promising cell therapy technology and significantly improved the fat graft retention. Initially applied for cosmetic breast and facial enhancement, CAL has found a potential use for breast reconstruction in breast cancer patients. However, more challenges emerge related to CAL including lack of a standardized surgical procedure, the controversy in the effectiveness of CAL, and the potential oncogenic risk of ADSCs in cancer patients. In this review, we summarized the latest research and intended to give an outline involving the biological characteristics of ADSCs as well as the preclinical and clinical application of ADSCs.
近年来，脂肪来源的基质/干细胞（ADSC）生物学的发展为组织工程和再生医学提供了新的希望。由于其多能性、旁分泌活性和免疫调节功能，ADSCs 已广泛应用，并在动物和人体临床试验中对自身免疫性疾病、神经退行性疾病和缺血性疾病的治疗显示出显著的疗效。基于 ADSCs 的细胞辅助脂肪转移（CAL）已成为一种很有前途的细胞治疗技术，显著提高了脂肪移植物的保留率。最初应用于美容乳房和面部增强，CAL 已发现对乳腺癌患者的乳房重建有潜在的用途。然而，与 CAL 相关的更多挑战出现了，包括缺乏标准化的手术程序、CAL 效果的争议以及 ADSCs 在癌症患者中的潜在致癌风险。在这篇综述中，我们总结了最新的研究成果，并旨在概述 ADSCs 的生物学特性以及 ADSCs 的临床前和临床应用。
