Wang Qiang, Chen Cheng-Xin, Zuo Shi, Cao Kun, Li Hai-Yang
Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University Guiyang, Guizhou, P. R. China.
School of Clinical Medicine, Guizhou Medical University Guiyang, Guizhou, P. R. China.
Am J Transl Res. 2023 Aug 15;15(8):5364-5372. eCollection 2023.
The number of articles on the relationships between the intestinal microbiota and liver diseases has continued to increase. The aim of this study was to assess publications on this topic, identify research hotspots, and predict trends of future research. Articles on this topic published from 2001 to 2021 were obtained from the Web of Science Core Collection. Bibliometric analysis and visualization were performed to identify research hotspots and trends with the use of the online bibliometric analysis platform, VOSviewer, and CiteSpace. In total, 4415 articles were included for bibliometric analysis. The annual output of research on this topic gradually increased over the past 21 years. China contributed the most publications (1254), while the United States was the core (centrality = 0.35) of the country-cooperation network and Schnabl B published the most articles (n = 80). High-frequency keywords included "gut microbiota", "inflammation", "obesity", "insulin resistance", "disease", "fatty liver disease", "metabolism", and "probiotics". The keywords that have burst in recent years include "intestinal microbiota", "dysbiosis", and "gut-liver axis". The relationships between dysbiosis of the intestinal microbiota and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), cirrhosis, and hepatocellular carcinoma (HCC), are current research hotspots. Treatment for NAFLD, nonalcoholic steatohepatitis, cirrhosis, and HCC via regulation of the intestinal microbiota is predicted as a research hotspot in the following years, especially immunotherapy for HCC. These findings should prove helpful to scholars to direct future research on the relationships between the intestinal microbiota and liver diseases.
关于肠道微生物群与肝脏疾病之间关系的文章数量持续增加。本研究的目的是评估关于该主题的出版物，确定研究热点，并预测未来研究趋势。从科学网核心合集中获取了2001年至2021年发表的关于该主题的文章。使用在线文献计量分析平台VOSviewer和CiteSpace进行文献计量分析和可视化，以确定研究热点和趋势。总共纳入4415篇文章进行文献计量分析。在过去21年中，该主题的研究年产出逐渐增加。中国的出版物数量最多（1254篇），而美国是国家合作网络的核心（中心性 = 0.35），Schnabl B发表的文章最多（n = 80篇）。高频关键词包括“肠道微生物群”、“炎症”、“肥胖”、“胰岛素抵抗”、“疾病”、“脂肪肝疾病”、“代谢”和“益生菌”。近年来出现爆发的关键词包括“肠道微生物群”、“生态失调”和“肠-肝轴”。肠道微生物群生态失调与肝脏疾病（如非酒精性脂肪性肝病（NAFLD）、肝硬化和肝细胞癌（HCC））之间的关系是当前的研究热点。预计未来几年通过调节肠道微生物群治疗NAFLD、非酒精性脂肪性肝炎、肝硬化和HCC将成为研究热点，尤其是HCC的免疫治疗。这些发现应有助于学者指导未来关于肠道微生物群与肝脏疾病之间关系的研究。
