2002 年至 2022 年胆汁酸与非酒精性脂肪性肝病相关性的研究趋势和热点：文献计量分析。

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome of the liver, and its incidence is increasing worldwide. Accumulating evidence suggests that bile acids are associated with NAFLD. Although many studies on bile acids and NAFLD have been published over the past 20 years, the authors of this study have not found a relevant bibliometric analysis in this field. Therefore, this study aimed to evaluate the trend of publications, summarize current research hotspots and predict future research directions through bibliometric analysis in this field. METHOD: Articles related to bile acids and NAFLD published between 2002 and 2022 were obtained from the Science Citation Index-Expanded of Web of Science Core Collection. Microsoft Excel, CiteSpace, VOSviewer and Bibliometric Online Analysis Platform were used to analyse the publication trends and research hotspots in this field. RESULTS: Among the articles published between 2002 and 2022, we retrieved 1284 articles related to bile acids and NAFLD, and finally included 568 articles. The USA was dominant until 2020, after which China surpassed the USA to become the dominant force. These two countries cooperate the most closely, and are also the most active in international cooperation. The University of California (UCL) was the most published institution, with a total of 31 publications. There were six authors who have published nine articles and ranked first. The keywords cluster labels show the 10 main clusters: #0fatty liver, #1obeticholic acid, #2oxidative stress, #37 alpha hydroxy 4 cholesten 3 one, #4deoxycholic acid, #5nonalcoholic fatty liver disease, #6mouse model, #7fibroblast growth factor 21, #8animal models, #9high-fat diet. Keywords burst analysis revealed a higher intensity of study for the nuclear receptor, FXR, and metabolic syndrome. CONCLUSION: Bile acids have become an important research direction in the field of NAFLD, and the intervention of gut microbiota in NAFLD by acting on bile acids may become a potential hotspot for future research. This study provides reference and guidance for future research, and will help scholars better explore the field and innovatively discover the mechanisms and treatments of NAFLD.

背景：非酒精性脂肪性肝病（NAFLD）是一种肝脏代谢综合征，其发病率在全球范围内呈上升趋势。越来越多的证据表明，胆汁酸与 NAFLD 有关。尽管在过去的 20 年中已经发表了许多关于胆汁酸和 NAFLD 的研究，但作者在该领域尚未发现相关的文献计量分析。因此，本研究旨在通过该领域的文献计量分析评估出版物趋势，总结当前研究热点并预测未来研究方向。

方法：从 Web of Science 核心合集的科学引文索引扩展版中获取 2002 年至 2022 年间发表的与胆汁酸和 NAFLD 相关的文章。使用 Microsoft Excel、CiteSpace、VOSviewer 和 Bibliometric Online Analysis Platform 分析该领域的出版物趋势和研究热点。

结果：在 2002 年至 2022 年期间发表的文章中，我们检索到 1284 篇与胆汁酸和 NAFLD 相关的文章，最终纳入 568 篇。直到 2020 年，美国一直占据主导地位，此后中国超过美国成为主导力量。这两个国家合作最为密切，也是国际合作最活跃的国家。加利福尼亚大学（UCL）是发表文章最多的机构，共发表 31 篇文章。有六位作者发表了 9 篇文章，排名第一。关键词聚类标签显示了 10 个主要聚类：#0脂肪肝，#1奥贝胆酸，#2氧化应激，#37α羟基 4 胆甾醇 3 酮，#4脱氧胆酸，#5非酒精性脂肪性肝病，#6小鼠模型，#7成纤维细胞生长因子 21，#8动物模型，#9高脂饮食。关键词突发分析显示，核受体 FXR 和代谢综合征的研究强度更高。

结论：胆汁酸已成为 NAFLD 领域的一个重要研究方向，通过作用于胆汁酸来干预肠道微生物群在 NAFLD 中的作用可能成为未来研究的潜在热点。本研究为未来的研究提供了参考和指导，将有助于学者更好地探索该领域，并创新性地发现 NAFLD 的机制和治疗方法。