非酒精性脂肪性肝病（NAFLD）肠道-肝脏轴的全球发表趋势和研究热点：文献计量分析。
Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis.
机构信息
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
出版信息
Front Endocrinol (Lausanne). 2023 Mar 9;14:1121540. doi: 10.3389/fendo.2023.1121540. eCollection 2023.
BACKGROUND
Nonalcoholic Fatty Liver Disease(NAFLD)refers to a spectrum of diseases ranging from simple liver steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Bidirectional cross-talk between the gut-liver axis plays an important role in the pathogenesis of NAFLD. To learn more about the gut-liver axis in NAFLD, this study aims to provide a comprehensive analysis from a bibliometric perspective.
METHOD
Literature related to the gut-liver axis in NAFLD from 1989 to 2022 was extracted from the Web of Science Core Collection. Based on Microsoft Excel, CiteSpace and Vosviewer, we conducted to analyze the number of publications, countries/regions, institutions, authors, journals, references, and keywords.
RESULTS
A total of 1,891 literature since 2004 was included, with the rapid growth of the number of papers on the gut-liver axis in NAFLD annually. These publications were mainly from 66 countries and 442 institutions. Of the 638 authors analyzed, Bernd Schnabl was the one with the most publications, and Patrice D. Cani was the one with the most co-citations. is the journal with the most articles published, and is the journal with the most citations. The most common keywords are gut microbiota, inflammation, and insulin instance, which are current research hotspots. Short-chain fatty acid, , randomized controlled trial in clinical, and diabetes mellitus represent the research frontiers in this field and are in a stage of rapid development.
CONCLUSION
This is the first study to conduct a comprehensive bibliometric analysis of publications related to the gut-liver axis in NAFLD. This study reveals that gut microbiota, inflammation, insulin resistance, short-chain fatty acids, and randomized controlled trial will be the hotspots and new trends in the gut-liver axis in NAFLD research, which could provide researchers with key research information in this field and is helpful for further exploration of new research directions.
背景
非酒精性脂肪性肝病（NAFLD）是指从单纯性肝脂肪变性到非酒精性脂肪性肝炎（NASH）和肝硬化的一系列疾病。肠-肝轴的双向相互作用在 NAFLD 的发病机制中起着重要作用。为了更多地了解 NAFLD 中的肠-肝轴，本研究旨在从文献计量学的角度进行全面分析。
方法
从 Web of Science 核心合集数据库中提取了 1989 年至 2022 年与 NAFLD 肠-肝轴相关的文献。基于 Microsoft Excel、CiteSpace 和 Vosviewer，我们对出版物数量、国家/地区、机构、作者、期刊、参考文献和关键词进行了分析。
结果
共纳入了 1891 篇文献，其中 2004 年以来每年关于 NAFLD 肠-肝轴的论文数量呈快速增长趋势。这些出版物主要来自 66 个国家和 442 个机构。在分析的 638 位作者中，Bernd Schnabl 发表的文献最多，Patrice D. Cani 的被引频次最高。发表文章最多的期刊是 ，被引频次最高的期刊是 。最常见的关键词是肠道微生物群、炎症和胰岛素抵抗，这些都是当前的研究热点。短链脂肪酸、随机对照临床试验和糖尿病代表了该领域的研究前沿，处于快速发展阶段。
结论
这是首次对与 NAFLD 肠-肝轴相关的出版物进行全面的文献计量学分析。本研究揭示了肠道微生物群、炎症、胰岛素抵抗、短链脂肪酸和随机对照临床试验将成为 NAFLD 肠-肝轴研究的热点和新趋势，可为研究人员提供该领域的关键研究信息，有助于进一步探索新的研究方向。
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