微小RNA-182通过激活Wnt/β-连环蛋白轴促进宫颈癌进展。
miR-182 promotes cervical cancer progression via activating the Wnt/β-catenin axis.
作者信息
Gao Fei, Yin Jilai, Wang Yongcun, Li Hao, Wang Daping
机构信息
The First Affiliated Hospital of Hainan Medical College Haikou, Hainan, China.
The Affiliated Hospital of Guangdong Medical University Zhanjiang, Guangdong, China.
出版信息
Am J Cancer Res. 2023 Aug 15;13(8):3591-3598. eCollection 2023.
Abstract
Cervical cancer (CC) is among the leading causes of cancer-associated mortality in women worldwide; yet the molecular regulators involved in its progression are unclear. This study found that miR-182 was overexpressed in CC tissues when compared with adjacent normal tissues. Moreover, it found that miR-182 expression was significantly positively correlated with distant metastasis in patients with CC. Interestingly, experiments showed that overexpression and inhibition of miR-182 promoted and suppressed the growth of CC cells, respectively. The tumor-promoting effects of miR-182 on CC progression were achieved via the Wnt/β-catenin axis and its downstream genes. Thus, this study revealed the potential of miR-182/β-catenin as an effective new target for CC treatment.
摘要
宫颈癌（CC）是全球女性癌症相关死亡的主要原因之一；然而，其进展过程中涉及的分子调节因子尚不清楚。本研究发现，与相邻正常组织相比，miR-182在CC组织中过表达。此外，研究发现CC患者中miR-182表达与远处转移显著正相关。有趣的是，实验表明，miR-182的过表达和抑制分别促进和抑制了CC细胞的生长。miR-182对CC进展的促肿瘤作用是通过Wnt/β-连环蛋白轴及其下游基因实现的。因此，本研究揭示了miR-182/β-连环蛋白作为CC治疗有效新靶点的潜力。
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