Willems Y E, deSteiguer A, Tanksley P T, Vinnik L, Främke D, Okbay A, Richter D, Wagner G G, Hertwig R, Koellinger P, Tucker-Drob E M, Harden K P, Raffington L
Max Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin.
Population Research Center, The University of Texas, Austin.
medRxiv. 2023 Sep 1:2023.08.30.23294816. doi: 10.1101/2023.08.30.23294816.
Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DNAm) measures of biological aging quantified in children, adolescents, and adults, and (2) whether biological aging measured in buccal DNAm is associated with self-reported health. Following preregistered analyses, we computed two DNAm measures of advanced biological age (PhenoAge and GrimAge Acceleration) and a DNAm measure of pace of aging (DunedinPACE) in buccal samples from the German Socioeconomic Panel Study (SOEP-G[ene], = 1058, age range 0-72, = 42.65) and saliva samples from the Texas Twin Project (TTP, = 1327, age range 8-20, = 13.50). We found that lower self-control was associated with advanced biological age in older adults ( =-.34), but not young adults, adolescents or children. This association was not accounted for by statistical correction for socioeconomic contexts, BMI, or genetic correlates of low self-control. Moreover, a faster pace of aging and advanced biological age measured in buccal DNAm were associated with worse self-reported health ( =.13 to = .19). But, effect sizes were weaker than observations in blood, thus customization of DNAm aging measures to buccal and saliva tissues may be necessary. Our findings are consistent with the hypothesis that self-control is associated with health via pathways that accelerate biological aging in older adults.
自我控制是一种人格维度，与更好的身体健康和更长的寿命相关。在此，我们研究了：（1）自我控制是否与儿童、青少年和成年人中量化的口腔和唾液DNA甲基化（DNAm）生物衰老指标相关；（2）通过口腔DNAm测量的生物衰老是否与自我报告的健康状况相关。经过预先注册的分析，我们在德国社会经济面板研究（SOEP-G[ene]，n = 1058，年龄范围0 - 72岁，平均年龄 = 42.65岁）的口腔样本以及德克萨斯双胞胎项目（TTP，n = 1327，年龄范围8 - 20岁，平均年龄 = 13.50岁）的唾液样本中，计算了两种晚期生物年龄的DNAm指标（PhenoAge和GrimAge加速）以及一种衰老速度的DNAm指标（DunedinPACE）。我们发现，在老年人中，较低的自我控制与晚期生物年龄相关（r = -0.34），但在年轻人、青少年或儿童中并非如此。这种关联无法通过对社会经济背景、体重指数或低自我控制的遗传相关性进行统计校正来解释。此外，口腔DNAm测量的更快衰老速度和晚期生物年龄与自我报告的较差健康状况相关（r = 0.13至r = 0.19）。但是，效应大小比血液中的观察结果弱，因此可能有必要针对口腔和唾液组织定制DNAm衰老指标。我们的研究结果与以下假设一致，即自我控制通过加速老年人生物衰老的途径与健康相关。
