口腔鳞状细胞癌患者血清岩藻糖水平的评估：一项病例对照研究。
Assessment of Serum Fucose Level among Oral Squamous Cell Carcinoma Patients: A Case-Control Study.
作者信息
Ashem Albert, Mehta Dhaval N, Singh Deepak N, Singh Khwairakpam C, Anupriya Ch, Devi Ahanthem N
机构信息
Department of Oral Medicine and Radiology, Dental College, RIMS, Imphal, Manipur, India.
Department of Oral Medicine and Radiology, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India.
出版信息
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 2):S878-S880. doi: 10.4103/jpbs.jpbs_91_23. Epub 2023 Jul 11.
BACKGROUND
Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the monosaccharides. Numerous illness conditions and cancers have been linked to increased levels of protein-bound fucose.
MATERIALS AND METHODS
In the current study, the serum fucose levels of patients with oral squamous cell carcinoma (OSCC) and healthy individuals were assessed and compared. The present study included a total of 30 OSCC patients and 30 healthy controls. The Winzler method was used to estimate the serum L-fucose levels using a spectrophotometer (Spectronic 20, Thermo Fisher Scientific, USA).
RESULTS
Age and sex had no effect on serum fucose levels. In contrast to healthy individuals, OSCC patients' mean serum fucose levels significantly increased. In conclusion, patients with OSCC can benefit from the use of serum fucose as an investigative biomarker.
背景
血清糖蛋白由多种单糖组成，在恶性肿瘤（一种细胞行为紊乱）中会发生改变。L-岩藻糖是一种甲基戊糖，是大多数血浆糖蛋白中的末端糖，是单糖之一。许多疾病状况和癌症都与蛋白质结合岩藻糖水平升高有关。
材料与方法
在本研究中，评估并比较了口腔鳞状细胞癌（OSCC）患者和健康个体的血清岩藻糖水平。本研究共纳入30例OSCC患者和30例健康对照。使用温兹勒方法，通过分光光度计（Spectronic 20，美国赛默飞世尔科技公司）估算血清L-岩藻糖水平。
结果
年龄和性别对血清岩藻糖水平没有影响。与健康个体相比，OSCC患者的平均血清岩藻糖水平显著升高。总之，OSCC患者可受益于将血清岩藻糖用作一种研究性生物标志物。
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