Rao V R, Krishnamoorthy L, Kumaraswamy S V, Ramaswamy G
Department of Biochemistry, Kidwai Memorial Institute of Oncology, Bangalore, India.
Cancer Detect Prev. 1998;22(3):237-40. doi: 10.1046/j.1525-1500.1998.0oa04.x.
Total sialic acid (TSA), lipid-associated sialic acid (LASA), and fucose were estimated in sera of 35 patients with precancerous lesion of the oral cavity, 68 patients with cancer of the oral cavity, and 25 age- and sex-matched non-chewers of both tobacco and betal nut and nonsmokers as controls. Significant elevation in the serum levels of TSA and LASA were observed in patients with the precancerous and cancer lesions when compared with the controls. Serum TSA levels were elevated significantly in patients with cancer when compared with those with precancerous lesions. Circulating TSA and LASA levels were found to reflect tumor burden and correlated well with stage of the disease. However, serum fucose levels did not show an increase corresponding to stage of the disease. The results suggests that combined evaluation of these markers may be useful in predicting early malignant change and also in assessing the spread and invasiveness of the disease in cancer of the oral cavity.
对35例口腔癌前病变患者、68例口腔癌患者以及25例年龄和性别匹配的非烟草和槟榔咀嚼者且不吸烟者作为对照者的血清进行总唾液酸（TSA）、脂质相关唾液酸（LASA）和岩藻糖含量测定。与对照组相比，癌前病变和癌症患者血清中TSA和LASA水平显著升高。与癌前病变患者相比，癌症患者血清TSA水平显著升高。发现循环TSA和LASA水平反映肿瘤负荷，且与疾病分期密切相关。然而，血清岩藻糖水平并未随疾病分期相应升高。结果表明，联合评估这些标志物可能有助于预测早期恶性变化，也有助于评估口腔癌疾病的扩散和侵袭性。
