UCL Genetics Institute, University College London, London, UK
Centre for Psychiatry, Queen Mary University of London, London, UK.
Behav Brain Sci. 2023 Sep 11;46:e212. doi: 10.1017/S0140525X22002448.
The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.
多基因评分（PGS）存在问题被低估了。事实上，它们是特定于祖先的，这意味着与社会人口因素相关的偏见是不可能避免的。此外，获取 DNA 的要求将对研究设计和所需资源产生深远影响，并可能引入招募偏差。PGS 对社会科学研究没有帮助。
