Research and Development, EvolvingFX, LLC, Fort Wayne, IN, USA
John Ochsner Heart & Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, USA
Behav Brain Sci. 2023 Sep 11;46:e209. doi: 10.1017/S0140525X22002436.
"Challenging the utility of polygenic scores for social science" is a compelling but limited critique. Phenotypic development is sensitive to both initial conditions - from conception to senescence. Thus, gene-centric analyses are misleading (and often meaningless) because gene products are transformed, and their phenotypic 'effects' combined and attenuated with successive propagations from molecular and cellular contexts to organismal and social environments.
“质疑多基因评分在社会科学中的效用”是一个引人注目的但有限的批评。表型发育对初始条件敏感——从受孕到衰老。因此，以基因为中心的分析具有误导性（而且往往毫无意义），因为基因产物会发生转化，并且它们的表型“效应”在从分子和细胞环境到机体和社会环境的连续传播中被组合和削弱。
