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当前多基因评分的可解决局限性并不能为受遗传混淆的社会科学开脱。

Tractable limitations of current polygenic scores do not excuse genetically confounded social science.

机构信息

Social, Genetic, and Developmental Psychiatry Centre, King's College London, London, UK

UCLA Anderson School of Management, Los Angeles, CA, USA.

出版信息

Behav Brain Sci. 2023 Sep 11;46:e222. doi: 10.1017/S0140525X22002503.

Abstract

Burt's critique of using polygenic scores in social science conflates the "scientific costs" of sociogenomics with "sociopolitical and ethical" concerns. Furthermore, she paradoxically enlists recent advances in controlling for environmental confounding to argue such confounding is scientifically "intractable." Disinterested social scientists should support ongoing efforts to improve this technology rather than obstructing progress and excusing genetically confounded research.

摘要

伯特对在社会科学中使用多基因评分的批评混淆了社会基因组学的“科学成本”与“社会政治和伦理”方面的担忧。此外,她自相矛盾地利用最近在控制环境混杂因素方面的进展来论证这种混杂因素在科学上是“难以解决的”。不偏不倚的社会科学家应该支持正在进行的改进这项技术的努力,而不是阻碍进展并为受基因混杂影响的研究开脱。

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