Urology Department of Affiliated Hospital of Chengdu University, Chengdu, 610000, Sichuan, China.
Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Sirjan Branch, Sirjan, Iran.
Ann Clin Microbiol Antimicrob. 2023 Sep 11;22(1):83. doi: 10.1186/s12941-023-00628-5.
Urogenital Mycoplasma infections are considered an important public health problem, owing to the presence of antibiotic resistance or decreased susceptibility, the treatment options are limited.
Therefore, this meta-analysis aimed to estimate resistance rates of genital Mycoplasmas to tetracyclines (tetracycline, doxycycline, and minocycline).
We searched the relevant published studies in PubMed, Scopus, and Embase until 3, March 2022. All statistical analyses were carried out using the statistical package R.
The 26 studies included in the analysis were performed in 15 countries. In the metadata, the proportions of tetracycline, doxycycline, and minocycline resistance in Mycoplasma and Ureaplasma urogenital isolates were reported 14.2% (95% CI 8.2-23.2%), 5% (95% CI 3-8.1%), and 11.9% (95% CI 6.3-21.5%), respectively. According to the meta-regression, the tetracycline and minocycline resistance rate decreased over time. Although, the doxycycline resistance rate increased over time. There was a statistically significant difference in the tetracyclines resistance rates between different continents/countries (P < 0.05).
The prevalence rate and antibiotic susceptibility profiles vary geographically. Therefore, rigorous or improved antimicrobial stewardship, contact tracing, and enhanced intensive surveillance systems are necessitated for preventing the emergence and further spreading of tetracyclines resistance in genital Mycoplasmas.
由于存在抗生素耐药性或敏感性降低，泌尿生殖支原体感染被认为是一个重要的公共卫生问题，治疗选择有限。
因此，本荟萃分析旨在估计生殖支原体对四环素（四环素、强力霉素和米诺环素）的耐药率。
我们在 PubMed、Scopus 和 Embase 中搜索了截至 2022 年 3 月 3 日的相关已发表研究。所有统计分析均使用 R 统计软件包进行。
纳入分析的 26 项研究在 15 个国家进行。在元数据中，报告了支原体和脲原体泌尿生殖分离株中四环素、强力霉素和米诺环素耐药的比例分别为 14.2%（95%CI 8.2-23.2%）、5%（95%CI 3-8.1%）和 11.9%（95%CI 6.3-21.5%）。根据荟萃回归分析，四环素和米诺环素的耐药率随时间降低。然而，强力霉素的耐药率随时间增加。不同大洲/国家之间四环素耐药率存在统计学差异（P<0.05）。
耐药率和抗生素敏感性谱在地理上存在差异。因此，需要严格或改进抗菌药物管理、接触者追踪和加强强化监测系统，以防止生殖支原体中四环素耐药的出现和进一步传播。
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